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Recent Comments
The dynamic interplay between enzymes and natural products represents a driving force in modern chemical, biological, and pharmaceutical research, offering a rich foundation for both fundamental discoveries and applied innovations. This special collection brings together eight recent contributions published in Natural Products and Bioprospecting, each presenting significant advances at the interface of enzymology and natural product research.By integrating insights from these dimensions, the contributions in this collection illustrate how advances in mechanistic enzymology, synthetic biology, and natural product chemistry mutually reinforce one another, opening new avenues for translational applications. We trust that this compilation will serve as a valuable resource for researchers seeking to harness the synergy between enzyme engineering and natural product discovery.
This manuscript provides compelling evidence that Lobetyolin mitigates Aβ‑induced toxicity and oxidative stress in Caenorhabditis elegans, supported by coherent multi‑omics analyses. The identification of glutathione‑centered redox metabolism as a key intervention pathway offers a solid mechanistic basis for future mammalian investigations.
For researchers seeking novel therapeutic candidates, nidulin warrants immediate consideration for inclusion in preclinical development pipelines.