We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website. You can decide for yourself which categories you want to deny or allow. Please note that based on your settings not all functionalities of the site are available.
Further information can be found in our privacy policy.
Recent Comments
This comprehensive review published in Natural Products and Bioprospecting systematically delineates the latest advances in paeonol research within hepatology, transcending the conventional single-target narrative to establish a dual framework of "pan-spectrum disease coverage" and "orchestrated multi-mechanistic intervention." By synthesizing robust preclinical evidence, the article demonstrates how paeonol concurrently modulates the cardinal pathological processes of hepatic disorders—including oxidative stress, inflammatory cascades, fibrogenesis, and malignant transformation—thereby offering therapeutic potential across the complete pathological continuum from acute liver injury to hepatocellular carcinoma.
The review not only consolidates cutting-edge findings on paeonol's polypharmacology but also elucidates its strategic advantages as a multi-target candidate for chronic liver disease management. It provides crucial theoretical underpinnings and translational directions for the clinical application of natural products in hepatoprotection。
The dynamic interplay between enzymes and natural products represents a driving force in modern chemical, biological, and pharmaceutical research, offering a rich foundation for both fundamental discoveries and applied innovations. This special collection brings together eight recent contributions published in Natural Products and Bioprospecting, each presenting significant advances at the interface of enzymology and natural product research.By integrating insights from these dimensions, the contributions in this collection illustrate how advances in mechanistic enzymology, synthetic biology, and natural product chemistry mutually reinforce one another, opening new avenues for translational applications. We trust that this compilation will serve as a valuable resource for researchers seeking to harness the synergy between enzyme engineering and natural product discovery.
This manuscript provides compelling evidence that Lobetyolin mitigates Aβ‑induced toxicity and oxidative stress in Caenorhabditis elegans, supported by coherent multi‑omics analyses. The identification of glutathione‑centered redox metabolism as a key intervention pathway offers a solid mechanistic basis for future mammalian investigations.
For researchers seeking novel therapeutic candidates, nidulin warrants immediate consideration for inclusion in preclinical development pipelines.