Multifunctional-engineered NK cells overcome tumor immunosuppression by combining PDL1 and HLA-E targeting and endogenous IL15 production
Engineering the next generation of NK cells to overcome tumor immune escape. Our study presents a multifunctional, off-the-shelf NK cell platform that simultaneously targets PD-L1 and HLA-E while providing autonomous IL-15 support, achieving potent antitumor activity across multiple cancer models.
