Share your thoughts about the Research Communities in our survey.

About Pradeep Chaluvally-Raghavan

Dr. Chaluvally Raghavan is a Professor in the Department of Obstetrics and Gynecology at the Medical College of Wisconsin (MCW), Milwaukee. His lab is actively researching how RNA Binding Proteins (RBP) contribute to phase separation in cancer cells, stromal cells, and immune cells. The overarching goal of his lab is to characterize the cooperative oncogenesis orchestrated through RBPs for cancer progression. He is interested in developing and validating agents that abolish cooperative oncogenesis by inhibiting the actions of RBPs and their targets. His team is also testing how single-cell genomic technologies can serve as devices for efficient target identification and drug development for cancer therapy.

Silencing a Cancer Driver: Locked Nucleic Acid-Modified siRNA Treatment Provides a New Path for FXR1-Targeted Cancer Therapy

RNA-binding proteins (RBPs) are key drivers of cancer but remain largely undruggable. Using nanoparticle-delivered LNA-siRNA, we achieved selective inhibition of FXR1, demonstrating the feasibility of precision RBP targeting in preclinical cancer models.

Pradeep Chaluvally-Raghavan

Jun 18, 2026

Topics

Channels contributed to:

Behind the Paper

Details

Website

obgyn.mcw.edu
Email

pchaluvally@mcw.edu
Telephone

+01 414 955 2573

Cookies

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website. You can decide for yourself which categories you want to deny or allow. Please note that based on your settings not all functionalities of the site are available.

Further information can be found in our privacy policy.