dfPPI -epichaperomics_can_identify_disease-related_changes_in_protein-protein_interaction_networks (360p)

Presenting dfPPI (Epichaperomics): A novel omics approach unraveling disease secrets. Analyzing systems-level dysfunctions in cellular protein interactions, it unveils disease mechanisms and enables personalized treatments in cancers and neurodegenerative diseases.
Go to the profile of Gabriela Chiosis
Gabriela Chiosis
Professor, Memorial Sloan Kettering
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Nature
Nature Nature

Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation - Nature Communications

Epichaperomics allow the study of protein-protein interactions and their alterations, but probes have been limited to capturing HSP90 epichaperomes. Here, the authors introduce and validate a toolset of HSP70 epichaperome ligands, and use them in epichaperomics to identify a mechanism with which cancer cells can enhance the fitness of mitotic protein networks.

For more information please read:

https://cancercommunity.nature.com/posts/epichaperomics-illuminating-the-secrets-of-protein-interactions-in-disease-research

Go to the profile of Gabriela Chiosis
Gabriela Chiosis
Professor, Memorial Sloan Kettering

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Follow the Topic

Cancer Biology
Life Sciences > Biological Sciences > Cancer Biology
Systems Neuroscience
Life Sciences > Biological Sciences > Neuroscience > Systems Neuroscience
Neurodegenerative diseases
Life Sciences > Biological Sciences > Neuroscience > Neurological Disorders > Neurodegenerative diseases
Chemical Biology
Life Sciences > Biological Sciences > Chemical Biology
Proteomics
Life Sciences > Biological Sciences > Biological Techniques > Mass Spectrometry > Proteomics

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