New study: Vacuolar-type H⁺-ATPase-mediated extra-organellar buffering resolves mitochondrial dysfunction

Mitochondrial stress can reduce cellular performance and compromise survival. In our new work, we show that Vacuolar-type H⁺-ATPase (V-ATPase) supports an extra-organellar buffering response that helps restore mitochondrial function and improves cell fitness under mitochondrial stress.
Christopher B. Jackson Dec 08, 2025

Main message

  • V-ATPase-dependent buffering outside organelles contributes to recovery from mitochondrial dysfunction and promotes better cellular fitness during stress.

📌 Paper link: https://www.nature.com/articles/s41467-025-66656-1

#Mitochondria #VATPase #CellFitness #StressResponses #CellBiology