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We provided adequate data to support the crucial role of IL-18 in the development of EoE and showed the pretreatment with NLRP3 and caspase-1 inhibitors such as MCC950, BHB, and VX-765 protects against both food allergen- and aeroallergen-induced EoE pathogenesis in an EoE experimental model.
Pancreas or islet transplantation have been performed with the goal of curing diabetes mellitus. Recently, gene therapy and regenerative medicine using iPS or ES cells have also been newly proposed. However, these therapies are not sufficient for more than 500 million patients in the world 1.