Nature Communications
An open access, multidisciplinary journal dedicated to publishing high-quality research in all areas of the biological, health, physical, chemical and Earth sciences.
Evolutionary Studies Drive the Elucidation of Plant Natural Product Biosynthetic Pathways
Plant natural products are a major source of pharmaceuticals, with over one-third of FDA-approved drugs derived from natural products and their derivatives.
A unified model for interpretable latent embedding of multi-sample, multi-condition single-cell data
The advent of single-cell technologies has allowed us not only to generate comprehensive atlases of cell types in their 'normal' states, but also to understand how these cells change under various conditions. Here, we introduce GEDI, a framework to enable the analysis of these datasets.
Highly potent and broadly neutralizing anti-CD4 trimeric nanobodies inhibit HIV-1 infection by inducing CD4 conformational alteration
In one of our studies published in Nature Communications, we discover Nb457, an alpaca-derived nanobody with broad-spectrum anti-HIV-1 activity. Nb457 induces conformational changes in CD4, blocking viral entry. Its trimeric form achieves complete HIV-1 inhibition, promising treatments.
A Fiber for Electrons: The First Waveguide for Charged Particles in Vacuum
Electrons are key to modern technology, but guiding them over long distances remains challenging. We present the first vacuum-based electron waveguide utilizing Lagrange points, allowing efficient, extended electron transport. This innovation can revolutionize particle physics and quantum computing.
Self-powered and speed-adjustable sensor for abyssal ocean current measurements based on triboelectric nanogenerators
An ultra-compact deep-sea current sensor utilizing triboelectric nanogenerator technology is developed.Measurements conducted at a depth of 4,531 meters demonstrated that the instrument can accurately measure a wide range of flow velocities,from 0.02 m/s to 6.69 m/s,with the highest sensitivity.
Filling the spectral gap of persistent luminescence
By engineering sub-bandgap donor-acceptor states within a series of single-phase Ca(Sr)ZnOS crystals, the persistent luminescence emission peak can now be quasi-linearly tuned across a broad wavelength range (500–630 nm) as a function of Sr/Ca ratio.
PTMGPT2: An Interpretable Protein Language Model for Enhanced Post-Translational Modification Prediction
PTMGPT2 uses GPT-based architecture and prompt-based fine-tuning to predict post-translational modifications. It outperforms existing methods across 19 PTM types, offering interpretability and mutation analysis. This advances the understanding of protein function and disease research.
