CRISPR-Cas-based identification of a sialylated Human Milk Oligosaccharides utilization cluster in the infant gut commensal Bacteroides dorei
In the pursuit of carbon-negative pathways for future biosynthesis, researchers are engaged in deconstructing natural pathways into modular components and reassembling them akin to assembling LEGO blocks. This work serves as an inspiration, highlighting the diversity inherent in natural enzymes.
DeepRTAlign: toward accurate retention time alignment for large cohort mass spectrometry data analysis
Retention time (RT) alignment is a crucial step in large cohort proteomics and metabolomics studies. Here, the authors introduce DeepRTAlign, a deep learning tool for RT alignment that shows high identification sensitivity and quantitative accuracy.
Bacterially secreted amyloid fibrils were shown for the first time to catalyze the degradation of β-lactam antibiotics. This observation points to possible antibiotic resistance mechanisms associated with bacterial biofilms.