Nature Genetics
This journal publishes the very highest quality research in genetics, encompassing genetic and functional genomic studies on human and plant traits and on other model organisms.
Tandem kinase proteins across the plant kingdom
We are thrilled to share our recent publication in Nature Genetics, titled "Tandem kinase proteins across the plant kingdom." This study delves into the fascinating world of tandem kinase proteins (TKPs), uncovering their widespread presence and functional diversity across 104 plant genomes.
Behind the paper: A temporal cortex cell atlas highlights gene expression dynamics during human brain maturation
This blog post summarises the research leading to our recent publication in Nature Genetics. Our study contributes to the Human Cell Atlas consortium which aims to generate a comprehensive biological map of all cells within the human body.
Buyer’s remorse: how OAS1 genetic variants acquired by modern humans make them vulnerable to severe COVID-19
After almost 2.5 years of the COVID-19 pandemic, we are still trying to understand the factors contributing to differences in disease severity and who should be treated with what, when, and why. Our paper addresses some of these questions from genetic, molecular, evolutionary, and clinical angles.
Discovering a new ACE2 isoform; rallying to understand SARS-CoV-2 infection
COVID-19 forced a suspension to our primary ciliary dyskinesia (PCD) diagnostic service. Re-purposing nasal epithelial cell RNAseq data and bioresource, three University of Southampton groups joined forces and found a new “short” isoform of ACE2, the cell surface receptor for SARS-CoV-2 virus.
The long and the short of ACE2, the SARS-CoV-2 receptor
Just six months ago, angiotensin-converting enzyme 2 (ACE2) was hardly in our lexicon, but most people have heard about it by now because SARS-CoV-2 uses it as a receptor to enter cells. We explored the long and the short of ACE2: its transcriptionally independent and functionally distinct isoforms.
