Nature Protocols
This journal publishes secondary research articles and covers new techniques and technologies, as well as established methods, used in all fields of the biological, chemical and clinical sciences.
Bioconjugates of photon-upconversion nanoparticles for cancer biomarker detection and imaging
Photon-upconversion nanoparticles that convert two or more low-energy photons to one photon of UV, visible or NIR light enable the detection and imaging of cancer markers without optical background interference.
Exploring the virtual chemical space with deep learning-accelerated docking
We have developed a deep learning method for large-scale virtual screening in a fraction of the time required by conventional docking. Deep Docking can be used in conjunction with any docking program and enables the screening of billions of compounds in a fast and efficient way.
An Epigenetic 2-for-1 Deal: Joint-Profiling of DNA Methylation and Chromatin Accessibility
We have detailed a method for profiling DNA methylation and chromatin accessibility state from a single fragment library. This joint-profiling method, termed ATAC-Me, can now be applied in diverse cellular models to shed light on the complicated relationship between these two epigenetic features.
Using phosphatase inhibitor beads coupled with mass spectrometry (PIB-MS) to parse phosphoprotein phosphatase signaling.
In our Nature Protocol, we present step by step instructions on how to make phosphatase inhibitor beads, enrich lysates for phosphoprotein phosphatases, multiplex, phosphopeptide enrich, and analyze samples by mass spectrometry to systematically study the major drivers of protein dephosphorylation.