Nature
A weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions.
A first global atlas of the bacterial microbiome in the world’s glacier-fed streams
Glaciers and their streams are vanishing at an unprecedented pace because of global warming. What else are we potentially losing beside freshwater resources? In our article in Nature, we show what else besides freshwater resources we are potentially losing as glaciers shrink — a unique microbiome!
Linking tissue injury to neural precursor reprogramming in gliomagenesis
In this article, we provide a behind-the-scenes narrative of a new publication from my lab, led by Akram Hamed, published today in Nature: Gliomagenesis mimics an injury response orchestrated by neural crest-like cells. https://www.nature.com/articles/s41586-024-08356-2
How bad cholesterol is removed from blood
Cardiovascular disease is the number one cause of human mortality. New structural information helps to develop future therapeutic interventions for this chronic, human health problem.
Behind the Paper: A Bioinspired Journey to Needle-Free Drug Delivery
This blog post offers a glimpse into the research journey that led to our recent publication in Nature detailing microjet delivery (MiDe) systems for gastrointestinal drug delivery.
Human HDAC6 senses valine abundancy to regulate DNA damage
Valine specifically binds to the primate-specific SE14 repeat domain of HDAC6, retaining it in the cytoplasm. Valine deprivation triggers HDAC6 nuclear shift, increasing DNA demethylation and damage via TET2 activation. Valine restriction inhibits tumor growth, and enhances the effects of PARPis.
MSK-CHORD: an AI-enabled, 24,950-patient clinicogenomic dataset for cancer research
AI annotation, tumor genomic profiling, and combination of other siloed datasets enables creation of a clinicogenomic, harmonized oncologic real-world dataset (MSK-CHORD). MSK-CHORD allows for study of cancer genotype-phenotype relationships at a scale previously impossible.
