npj Parkinson's Disease
This journal publishes original basic science, translational and clinical research related to Parkinson's disease, including anatomy, etiology, genetics, cellular and molecular physiology, neurophysiology, epidemiology and therapeutic development and treatments.
A potential patient stratification biomarker for Parkinson's disease based on LRRK2-mediated cellular alterations in peripheral blood
A recent study substantiates a role for increased LRRK2 kinase activity in some idiopathic Parkinson's disease patients and suggests that blood-based patient stratification approaches hold promise in nominating patients who may benefit from LRRK2-related therapeutics.
Rescuing retromer in Parkinson's disease
Both Vp35 p.D620N and LRRK2 pathogenic variants cause late-onset, familial Parkinson's disease. In vivo, we show Vps35 p.D620N activates LRRK2 kinase activity, impairs the recycling and physiologic function of the dopamine transporter (DAT), and can be rescued by LRRK2 kinase inhibitors.
Wearable sensors provide early detection of progression in Parkinson’s Disease
For the first time, we have shown that it is possible to track disease progression of Parkinson's using machine learning to analyse data derived from sensor devices worn by patients.
Brainstem neuromelanin and iron MRI are novel imaging diagnostic markers for idiopathic and LRRK2 Parkinson’s disease.
Dopaminergic neuronal death in Parkinson’s disease is reflected by the loss of neuromelanin in substantia nigra and locus coeruleus. A novel automatic brainstem atlas of MRI neuromelanin-sensitive and iron images was used to differentiate Leucine-rich repeat kinase 2 gene carriers (LRRK2-PD) and idiopathic Parkinson’s disease.
