Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Behind the paper: ADNP is essential for sex-dependent hippocampal neurogenesis, through male unfolded protein response and female mitochondrial gene regulation
Surprisingly, dramatically different molecular pathways regulate adult neurogenesis in males and females. Importantly, these pathways are strongly impacted by the major autism/intellectual disability gene, ADNP and corrected by the ADNP neuroprotective site, the investigational drug davunetide.
The LEANORA study: Understanding the pharmacokinetics and pharmacogenomics of ribociclib in Black women
This study examined ribociclib pharmacokinetics and pharmacogenomics in 14 Black women with advanced breast cancer. The LEANORA study (NCT04657679) revealed that the ribociclib exposure and toxicity profile were similar between intermediate/normal and poor CYP3A5 metabolizers.
The climatic pattern of East Asia shifted in response to cratonic thinning in the Early Cretaceous
This manuscript examines a climate shift in East Asia linked to Cretaceous crustal thinning, analyzed through skarn garnet isotopes.
Old drugs, new tricks!
We explore the use of older bisphosphonates in the treatment of rare diseases of calcification.
Crosslinking degree variations enable programming and controlling soft fracture via sideways cracking
Under certain conditions, a crack in an elastomer propagates in a (sideways) direction parallel to the loading direction rather than perpendicularly in the (forward) direction of the notch. Then, the crack arrests and the material ahead can be further deformed enabling giant stretchability.
Bridging Dental Education and Technology
Can mobile apps revolutionize dental education? Our study developed and tested a smartphone-based app for teaching oral health needs assessment. While the app didn’t outperform traditional methods, students' enthusiasm for mobile learning highlights opportunities for future innovation.
Dynamics of the Blood Plasma Proteome During Hyperacute HIV-1 Infection
In our recent study in Nature Communications, we employed cutting-edge proteomics to explore changes in blood plasma proteins during early HIV-1 infection. The results advance our understanding of early host responses and highlight mechanisms that influence viral control and disease progression.
