Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Behind the Book | The evolution of quantum optics
My new textbook illustrates how quantum optics has come to play an enabling role in many areas of modern science
Cryo-EM Structure of Lipopolysaccharide Transporter LptDE Opens the Door to Antibiotics Design
Bacteria display very different biochemistry from human cells, which can be exploited for designing new antibiotics with less side-effects. Detailed insights into the architecture and function of LptDE transporter complexes has been made possible by new Cryo-EM structures.
Risk of winterization cost explains unpreparedness of Texan power system during winter storm Uri
In shock we witnessed the reports about the catastrophic failure of the Texan power system in February 2021. Although based in Europe, we started immediately analyzing why Texan energy-only markets have not given the right incentives to prepare the infrastructure against such rare extreme events.
A new CRISPR/Cas9 system with high editing efficiency and fidelity
We identified a novel type II-A nuclease, FrCas9. It possesses comparable cutting efficiency to SpCas9 but with lower off-target effect. Furthermore, the specific 5'-NNTA-3' PAM enables FrCas9 to directly target the TATA-box to regulate gene expression.
