Hepatocyte-targeting nanoparticles for enhanced hepatobiliary MRI

Hepatobiliary MRI can be enhanced by an ultrasmall nanoparticle composed of a manganese ferrite core and surface ligands binding to hepatocyte-specific transmembrane metal and anion transporters, as shown in small and large animals.

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The cover illustrates an ultrasmall nanoparticle with a manganese ferrite core and with surface ligands with high specificity for hepatocytes, for use as a contrast agent for imaging the liver and the biliary tree.

See Zhang et al.

Image: Haiming Fan, Northwest University. Cover design: Allen Beattie.

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