In this regard, it is currently offered a high Impact Topical collection focusing on “Discover Advances in the Design and Synthesis of Nano- Optics and Applications” ( https://link.springer.com/collections/iffbffbjdg ). Multivariable approaches and even Artificial Intelligence (AI) could be involved to design new materials; however different point of views and perspectives would be of interest. Thus, in this occasion it is stimulated to focus on an exponential increase of publications towards advances from Nanochemistry and Nanophysics to tune programable targeted Delivery of functions and properties. Therefore, multifunctional materials with varied optical active and non-optical active properties could be delivered through space and time from confined sizes within the Nanoscale and beyond. These could be part of emerging new materials with varied high impact interests from Optoelectronics, Nanophotonics, Biophotonics and Nanomedicine, etc.. So, all your proposals are welcomed to incorporate your Research insights and ideas in this Topical Collection!