Apr 2016 cover image

A new mechanism involving RNA modification to control HIV-1 replication and its interaction with the host immune system has been identified. HIV-1 infection in T cells triggers N6-methyladenosine modification in the viral and human RNAs. As shown in the illustration, methylation of two conserved adenosines in the stem loop region of a regulatory RNA structure in HIV-1 called Rev Response Element (RRE) enhanced binding of viral Rev protein to the RRE in vivo and influenced nuclear export of RNA. Viral and human RNAs are shown in red and deep blue colors, respectively.
Refers to Dynamics of the human and viral m6A RNA methylomes during HIV-1 infection of T cells
Gianluigi Lichinchi, Shang Gao, Yogesh Saletore, Gwendolyn Michelle Gonzalez, Vikas Bansal, Yinsheng Wang, Christopher E. Mason & Tariq M. Rana
Nature Microbiology 1, 16011 (2016)
Follow the Topic
-
Nature Microbiology
An online-only monthly journal interested in all aspects of microorganisms, be it their evolution, physiology and cell biology; their interactions with each other, with a host or with an environment; or their societal significance.
Related Collections
With collections, you can get published faster and increase your visibility.
Progress towards the Sustainable Development Goals
Publishing Model: Hybrid
Deadline: Ongoing
Please sign in or register for FREE
If you are a registered user on Research Communities by Springer Nature, please sign in