Microalgae oral drug carriers for gut microbiota homeostasis and intestinal disease/cancer treatment

We use microalga Spirulina platensis to construct an innovative oral delivery system for radioprotector Amifostine, showing comprehensive drug accumulation, effective radioprotection in the whole small intestine, beneficial gut microbiota homeostasis, and efficient disease treatment.
Microalgae oral drug carriers for gut microbiota homeostasis and intestinal disease/cancer treatment
Like

Share this post

Choose a social network to share with, or copy the shortened URL to share elsewhere

This is a representation of how your post may appear on social media. The actual post will vary between social networks

Protecting the whole small intestine from radiation-induced intestinal injury during the radiotherapy of abdominal or pelvic solid tumors remains an unmet clinical need. Amifostine is a promising selective radioprotector for normal tissues. However, its oral application in intestinal radioprotection remains challenging. Herein, we use microalga Spirulina platensis as a microcarrier of Amifostine to construct an oral delivery system. The system shows comprehensive drug accumulation and effective radioprotection in the whole small intestine that is significantly superior to free drug and its enteric capsule, preventing the radiation-induced intestine injury and prolonging the survival without influencing the tumor regression. It also shows benefits on the gut microbiota homeostasis and long-term safety. Based on a readily available natural microcarrier, this work presents a convenient oral delivery system to achieve effective radioprotection for the whole small intestine, providing a competitive strategy with great clinical translation potential.

figure 1

Fig. 1: Synthesis and characterization of SP@AMFa Schematic illustration of synthetic protocols and radioprotective mechanisms of SP@AMF. I. SP protects AMF from gastric destruction. II-IV. SP@AMF gradually degrades and slowly releases AMF through the whole small intestine (duodenum, jejunum and ileum). V. SP@AMF protects intestinal tissue from radiation-induced epithelial injury, inflammation, and fibrosis. VI. SP@AMF maintains the health of gut microbiota. b SP cultivated in medium and its lyophilized powder. c PBS suspension of the prepared SP@AMF and its bright-field microscope and SEM images. Scale bar = 20 µm. d Lyophilized powder of the mass prepared SP@AMF. The net weight of SP@AMF in the bottle is 7.331 grams. e Fourier transform infrared (FTIR) spectra of SP, AMF, and SP@AMF. f Drug loading efficiency (DLE) under various concentrations of AMF loading solution (n = 3 independent experiments). The data show means + SD. g Release profiles of AMF from SP@AMF in simulated intestinal fluid (SIF) after being treated by simulated gastric fluid (SGF) for 1 and 2 h. Untreated SP@AMF was used as control (n = 3 independent experiments). The data show means + SD. h pH values of the SGF supernatant containing different concentrations of SP@AMF (n = 3 independent experiments). The data show means + SD. P was calculated using two-tailed t-test.

Fig. 2

Fig. 2: In vitro, SP@AMF shows lower toxicity and more effective protection on normal cells than free AMF. a Viabilities of the IEC-6 cells (small intestinal epithelium cells) after incubating with various concentrations of SP, AMF, and SP@AMF for 24 h. The viabilities were determined by an MTT assay kit (n = 6 biologically independent cells). The data show means + SD. P was calculated using two-tailed t-test. b Calcein-AM/PI fluorescence images (green, living cell; red, dead cell) of the IEC-6 cells irradiated by 6 Gy X-ray (IR) (except for PBS group) after 1, 2, 3, or 4 h of incubation with the renewed medium in different groups. Scale bar = 100 µm. Experiment was repeated three times independently with similar results. cf Crystal violet staining (c, d) and quantification (e, f) of the surviving colonies of IEC-6 cells and CT26 cells (colorectal cancer cells) irradiated by 0, 2, 4, and 6 Gy X-ray in different treatment groups (PBS, SP, AMF, and SP@AMF) (n = 3 biologically independent cells). The data show means + SD. P was calculated using two-tailed t-test. n.s. no significance (P > 0.05).

figure 3

Fig. 3: Compared with free drug, SP-based system shows retention among villi, progressive degradation, and extensive drug distribution throughout the small intestine.

 In summary, we successfully constructed SP@AMF, a natural microcarrier-based orally delivered system, to effectively prevent the healthy intestine from radiation-induced damage in radiotherapy. Benefiting from the comprehensive intestinal biodistribution, the natural microcarrier, SP, significantly improved the radioprotection of AMF on the whole intestine. Possessing significant superiority to a commercial capsulation, the benefits on flora balance, as well as the high safety for long-term use, SP@AMF shows great potential to be applied in clinical radiotherapy of abdominal/pelvic tumors. Our study used readily available natural material to facilely construct a competitive radioprotective strategy with high translational potential in cancer radiotherapy.

Related reading:https://orcid.org/0000-0001-7114-1095  

https://www.nature.com/articles/s41467-022-28744-4

https://www.nature.com/articles/s41565-021-01040-w

https://www.nature.com/articles/s41467-021-25075-8

https://www.nature.com/articles/s41467-021-24961-5

https://www.nature.com/articles/s41467-021-21436-5  

https://www.nature.com/articles/s41578-020-00247-y 

https://www.nature.com/articles/s41467-019-12462-5

https://bioengineeringcommunity.nature.com/posts/tackling-covid-19-with-materials-science  https://bioengineeringcommunity.nature.com/posts/micropatterned-microfluidics-dendronized-fluorosurfactants-for-highly-stable-emulsions https://bioengineeringcommunity.nature.com/posts/nature-derived-2-dimensional-materials-for-cancer-therapy-and-sustainable-solutions https://bioengineeringcommunity.nature.com/posts/multi-targeted-reactive-oxygen-species-burst-for-cancer-therapy

https://bioengineeringcommunity.nature.com/posts/aladdin-magic-mat-non-printed-integrated-circuit-textile-for-wireless-theranostics

Related Cancer Theranostics works:

  1. D Gao, T Chen, Y Han, S Chen, Y Wang, X Guo, H Wang, X Chen, M Guo, Y Zhang, G Hong, X Zhang*, Z Tian*, Z Yang*. Targeting Hypoxic Tumors with Hybrid Nanobullets for Oxygen-independent Synergistic Photothermal-thermodynamic Therapy. Nano-Micro Letters, 2021,13, 99. (Featured Cover Paper)
  2. Y Yang, X Wei, N Zhang*, J Zheng, Q Wen, X Luo, C Lee, X Liu, X Zhang*, J Chen, C Tao, W Zhang*, X Fan*. A non-printed integrated-circuit textile for wireless theranostics. Nature Communications. 2021, 12, 4876.
  3. X Ji, L Ge, C Liu, Z Tang, Y Xiao, Z Lei, W Gao, S Blake, D De, X Zeng, N Kong,* X Zhang*, W Tao*. Capturing functional two-dimensional nanosheets from sandwich-structure vermiculite: synthesis and application in cancer theranostics. Nature Communications, 2021, 12, 1124.
  4. N Kong, H Zhang, C Feng, C Liu, Y Xiao, X Zhang, L Mei, J S Kim, W Tao, X Ji. Arsenene-mediated multiple independently targeted reactive oxygen species burst for cancer therapy. Nature Communications. 2021, 12, 4777.
  5. Z Tang†, N Kong†, X. Zhang†, Y Liu, P Hu, S Mou, P Liljeström, J Shi, W Tan, J S Kim, Y Cao, R Langer,  K W. Leong, O C. Farokhzad, W Tao. A materials-science perspective on tackling COVID-19. Nature Reviews Materials, 2020, 5, 847-860. (Featured Cover Paper, highly cited paper, accessed>20,000 times) 
  6. J Li, S Song, J Meng, Z Li,  X Liu*, L Tan, Y Zheng, C Li, K Yeung, Z Cui, Y Liang, S Zhu, X Zhang*, S Wu*. 2D MOF periodontitis photodynamic ion therapy. Journal of the American Chemical Society2021, 143, 37, 15427-15439. (Selected for“A Virtual Issue on Nanomedicine” collection papers from ACS Nano and JACS)
  7. Y Wang, D Gao, Y Liu, X Guo, S Chen, L Zeng, J Ma, X Zhang*, Z Tian*, Z Yang*. Immunogenic-Cell-Killing and Immunosuppression-Inhibiting Nanomedicine. Bioactive Materials, 2020, 6 (6), 1513-1527.
  8. J Yang†, X Zhang†, C Liu†, Z Wang, L Deng, C Feng, W Tao, X Xua, W Cui. Biologically Modified Nanoparticles as Theranostic Progress in Materials Science, 2021, 118, 100768.
  9. Z Yang, D Gao, X Guo, L Jin, J Zhang, Y Wang, S Chen, X Zheng, L Zeng, M Guo, X Zhang*, Z Tian*. Fighting immune cold and reprogramming immunosuppressive tumor microenvironment with red blood cell membrane-camouflaged ACS Nano, 2020, 14, 12, 17442-17457.
  10. D Wei, Y Yu, Y Huang,1 Y Jiang, Y Zhao, Z Nie, F Wang, W Ma, Z Yu, Y Huang, X Zhang, Z Liu, X Zhang, H Xiao. A Near-Infrared-II Polymer with Tandem Fluophores Demonstrates Superior Biodegradability for Simultaneous Drug Tracking and Treatment Efficacy Feedback. ACS Nano, 2021, 15 (3), 5428–5438.
  11. D Wei, Y Yu, X Zhang, Y Wang, H Chen, Y Zhao, F Wang, G Rong, W Wang, X Kang, J Cai, Z Wang, J Yin, M Hanif, Y Sun, G Zha, L Li, G Nie, H Xiao*. Breaking down the intracellular redox balance with diselenium nanoparticles for maximizing chemotherapy efficacy on patient-derived xenograft models. ACS Nano, 2020, 14, 12, 16984-16996.
  12. Z Lei, W Zhu, X Zhang, X Wang, P Wu. Bio-inspired ionic skin for theranostics hydrogel. Advanced Functional Materials, 2020, 2008020.
  13. D Gao, X Guo, X Zhang*, S Chen, Y Wang, T Chen, G Huang, Y Gao, Z Tian*, Z Yang*. Multifunctional phototheranostic nanomedicine for cancer imaging and treatment. Materials Today Bio. 2019, 5,100035. (Invited Paper, ESI highly cited paper, open access with a fee waiver, 99.983% excellence, 2nd most highly cited paper of Materials Today Bio)
  14. J Ouyang†, X Ji†, X Zhang†, C Feng, Z Tang, N Kong, A Xie, J Wang, X Sui, L Deng, Y Liu, J S Kim, Y Cao, W Tao*. In situ sprayed NIR-responsive, analgesic black phosphorus-based gel for diabetic ulcer Proceedings of the National Academy of Sciences of the United States of America (PNAS), 2020, 117 (46), 28667-28677. (highly cited paper, Highlighted by: MRS Bulletin Materials News)
  15. G Parekh, Y Shi, J Zheng, X Zhang*, S Leporatti. Nano-carriers for targeted delivery and biomedical imaging enhancement. Therapeutic Delivery, 2018, 9(6), 451-468.
  16.  C Liu, S Sun, Q Feng, Y Wu, N Kong, Z Yu, J Yao, X Zhang, W Chen, Z Tang,  Y Xiao, X Huang, A Lv, Y Cao, A Wu, T Xie, W Tao. Arsenene Nanodots with Selective Killing Effects and their Low‐Dose Combination with ß‐Elemene for Cancer Therapy. Advanced Materials, 33(37) (2021) 2102054.
  17. W Y Kim, M Won, S Koo, X Zhang, J S Kim. Mitochondrial H2Sn-Mediated Anti-Inflammatory Theranostics. Nano-Micro Letters,  2021, 13, 168.

Other Related Nature-derived/inspired materials/tea works:

  1. C Liu, S Sun, Q Feng, Y Wu, N Kong, Z Yu, J Yao, X Zhang, W Chen, Z Tang,  Y Xiao, X Huang, A Lv, Y Cao, A Wu, T Xie, W Tao. Arsenene Nanodots with Selective Killing Effects and their Low‐Dose Combination with ß‐Elemene for Cancer Therapy. Advanced Materials, 33(37) (2021) 2102054.
  2. Y Xie, J Yin, J Zheng, L Wang, J Wu, M Dresselhaus, X Zhang*. Synergistic cobalt sulfide/eggshell membrane carbon ACS Applied Materials & Interfaces. 2019, 11 (35), 32244-32250.
  3. N Kong, H Zhang, C Feng, C Liu, Y Xiao, X Zhang, L Mei, J S Kim, W Tao, X Ji. Arsenene-mediated multiple independently targeted reactive oxygen species burst for cancer therapy. Nature Communications. 2021, 12, 4777.
  4. X Ji, L Ge, C Liu, Z Tang, Y Xiao, Z Lei, W Gao, S Blake, D De, X Zeng, N Kong*, X Zhang*, W Tao*. Capturing functional two-dimensional nanosheets from sandwich-structure vermiculite: synthesis and application in cancer theranostics. Nature Communications, 2021,12,1124.
  5. Z Li, D Chu, Y Gao, L Jin*, X Zhang*, W Cui, J Li*. Biomimicry, biomineralization, and bioregeneration of bone using advanced three-dimensional fibrous hydroxyapatite Materials Today Advances. 2019,3,100014. (Invited open-access paper among most highly cited paper of Materials Today Advances)
  6. Z Lei, W Zhu, X Zhang, X Wang, P Wu. Bio-inspired ionic skin for theranostics hydrogel. Advanced Functional Materials, 2020, 2008020.
  7. L Jin, J Li, L Liu*, Z Wang*, X Zhang*. Facile synthesis of carbon dots with superior sensing. Applied Nanoscience, 2018, 755(3), 1-8.
  8. J Yang†, X Zhang†, C Liu†, Z Wang, L Deng, C Feng, W Tao, X Xua, W Cui. Biologically Modified Nanoparticles as Theranostic Progress in Materials Science, 2021, 118, 100768.
  9. Z Yang, D Gao, X Guo, L Jin, J Zhang, Y Wang, S Chen, X Zheng, L Zeng, M Guo, X Zhang*, Z Tian*. Fighting immune cold and reprogramming immunosuppressive tumor microenvironment with red blood cell membrane-camouflaged ACS Nano, 2020, 14, 12, 17442-17457.
  10. Y Wang, L Lu, G Zheng*, X Zhang*. Microenvironment-controlled micropatterned microfluidic model for biomimetic in-situ studies. ACS Nano, 2020, 14(8), 9861-9872. (Featured Cover Paper)
  11. Z Li†, X Zhang†, Z Guo, L Shi, L Jin, L Zhu, X Cai, J Zhang, Y Liu, Y Zhang, J Li. Nature-Derived Bionanomaterials for sustained release of 5-fluorouracil to inhibit subconjunctival fibrosis. Materials Today Advances, 2021, 11, 100150.  
  12. X Chen, Y Chen, L Zou, X Zhang, Y Dong, J Tang, D McClements, W Liu. Plant-based Nanoparticles Consisting of a Protein Core and Multilayer Phospholipid Shell: Fabrication, Stability, and  Journal of Agricultural and Food Chemistry, 2019, 67 (23), 6574-6584.
  13. P Tang, D Shen, Y Xu, X Zhang*, J Shi, J Yin*. Effect of fermentation conditions and the tenderness of tea leaves on the chemical components and sensory quality of fermented juice. Journal of Chemistry, 2018, 4312875,1-7.
  14. X Zhang*. Tea and cancer prevention. Journal of Cancer Research Updates, 2015, 4 (2), 65-73.
  15. Q Zhang, W Li, K Li, H Nan, C Shi, Y Zhang, Z Dai, Y Lin, X Yang, Y Tong, D Zhang, C Lu, L Feng, C Wang, X Liu, J Huang, W Jiang, X Wang, X Zhang, Eichler, Z. Liu, L. Gao. The Chromosome-Level Reference Genome of Tea Tree Unveils Recent Bursts of Non-autonomous LTR Retrotransposons in Driving Genome Size Evolution. Molecular plant 2020,13 (7), 935-938.
  16. Y Yang†, P Jin†, X Zhang†, N Ravichandran, H Ying, C Yu, H Ying, Y Xu, J Yin, K Wang, M Wu, Q New epigallocatechin gallate (EGCG) nanocomplexes co-assembled with 3-mercapto-1-hexanol and ß- lactoglobulin for improvement of antitumor activity. Journal of Biomedical Nanotechnology, 2017,13 (7), 805-814.
  17. X Zhang*, G Parekh, B Guo, X Huang, Y Dong, W Han, X Chen, G Polyphenol and Self-Assembly: Metal Polyphenol Nanonetwork for Drug Delivery and Biomedical Applications. Future Drug Discovery, 2019, 1 (1), FDD7. (Invited open-access paper with a fee waiver, most cited paper of the journal)

Related 2-dimentional/carbon materials works:

  1. Y Zheng, H Wei, P Liang, X Xu, X Zhang, H Li, C Zhang, C Hu, X Zhang, B Lei, W Wong, Y Liu, J Zhuang. Near-infrared-excited multicolor afterglow in carbon dots-based room-temperature phosphorescent materials. Angewandte Chemie, 2021, 202108696.  
  2. J Li, S Song, J Meng, Z Li,  X Liu*, L Tan, Y Zheng, C Li, K Yeung, Z Cui, Y Liang, S Zhu, X Zhang*, S Wu*. 2D MOF periodontitis photodynamic ion therapy. Journal of the American Chemical Society2021, 143, 37, 15427-15439. (Selected for“A Virtual Issue on Nanomedicine” collection papers from ACS Nano and JACS)
  3. G Li, C Liu, X Zhang, P Luo, G Lin, W Jiang. Highly photoluminescent carbon dots-based immunosensors for ultrasensitive detection of aflatoxin M1 residues in milk. Food Chemistry. 2021, 355, 129443.
  4. L Jin, X Guo, D Gao, G Tan, N Du, X Wang, Y Zhang, Z Yang*, X Zhang*. NIR-responsive MXene nanobelts for wound NPG Asia Materials. 2021,13, 24. Selected for the “Special Issue on Biomaterials and Health-care related Materials”.
  5. J Meng, J Li, J Liu, X Zhang*, G Jiang*, L Ma, Z Hu, S Xi, Y Zhao, M Yan, P Wang, X Liu, Q Li, J Liu, T Wu, L Mai*. Universal Approach to Fabricating Graphene-Supported Single-Atom Catalysts from  Doped ZnO  Solid ACS Central Science, 2020, 6(8), 1431–1440.
  6. J Cui, J Yin, J Zheng, J Meng, M Liao, T Wu, S He, S Wei, Z Xie, H Wang, M Dresselhaus, Y Xie*, J Wu*,  C Lu*, X Zhang*. Supermolecule cucurbituril subnanoporous carbon supercapacitor(SCSCS). Nano Letters, 2021, 21 (5), 2156–2164.
  7. J Meng, Z Liu, X Liu, W Yang, L Wang, Y Li, Y Cao, X Zhang*, L Mai*. Scalable fabrication and active site identification of MOF shell-derived nitrogen-doped carbon hollow frameworks for oxygen Journal of Materials Science & Technology, 2020, 66, 186-192.
  8. F Han, S Lv, Z Li, L Jin, B Fan*, J Zhang, R Zhang, X Zhang*, L Han, J Li*. Triple-synergistic 2D material- based dual-delivery antibiosis platform. NPG Asia Materials, 2020,12,15.
  9. J Ouyang†, X Ji†, X Zhang†, C Feng, Z Tang, N Kong, A Xie, J Wang, X Sui, L Deng, Y Liu, J S Kim, Y Cao, W Tao*. In situ sprayed NIR-responsive, analgesic black phosphorus-based gel for diabetic ulcer Proceedings of the National Academy of Sciences of the United States of America (PNAS), 2020, 117 (46), 28667-28677. (highly cited paper, Highlighted by: MRS Bulletin Materials News)
  10. H Zhou*, Z Wang, W Zhao, X Tong, X Jin, X Zhang*, Y Yu, H Liu, Y Ma, S Li, W Robust and sensitive pressure/strain sensors from solution processable composite hydrogels enhanced by hollow-structured conducting polymers. Chemical Engineering Journal, 2020, 403, 126307.
  11. X Ji, L Ge, C Liu, Z Tang, Y Xiao, Z Lei, W Gao, S Blake, D De, X Zeng, Na Kong*, X Zhang*, W Tao*. Capturing functional two-dimensional nanosheets from sandwich-structure vermiculite: synthesis and application in cancer theranostics. Nature Communications, 2021, 12, 1124.
  12. X Ji, L Ge, C Liu, Z Tang, Y Xiao, Z Lei, W Gao, S Blake, D De, X Zeng, Na Kong*, X Zhang*, W Tao*. Capturing functional two-dimensional nanosheets from sandwich-structure vermiculite: synthesis and application in cancer theranostics. Nature Communications, 2021, 12, 4777.
  13. J Meng, Q He, L Xu, X Zhang, F Liu, X Wang, Q Li, X Xu, G Zhang, C Niu, Z Identification of phase control of carbon-confined Nb2O5 nanoparticles towards high-performance lithium  storage.  Advanced Energy Materials, 2019, 9 (18), 1802695.
  14. J Wu, F Xu, S Li, Q, Liu, X Zhang, Q Liu, R Fu, D Wu. Porous polymers as multifunctional material platforms toward task‐specific applications. Advanced  Materials,  2019,  31(4),  1802922.  (Citation>145,  ESI Highly Cited Paper, Invited Paper)
  15. B Zheng, X Lin, X Zhang, D Wu, K Matyjaszewski. Emerging functional porous polymeric and carbonaceous materials for environment treatment and energy storage. Advanced Functional  Materials, 2019, 1907006. (Invited Paper)
  16. R Huang, X Chen, Y Dong, X Zhang*, Y Wei, Z Yang, W Li, Y Guo, J Liu, Z Yang*, H Wang*, L Jin*.

    MXene composite nanofibers for cell culture and tissue engineering. ACS Applied Bio Materials. 2020, 3(4), 2125-2131. 

  17. J Ouyang, C Feng, X Zhang, N, Kong, W. Tao. Black Phosphorus in Biomedical applications: Evolutionary Journey from Monoelemental Materials to Composite Materials. Accounts of Materials Research. 2021, 2, 7, 489–500. (Featured Cover Paper, ACS Editors` Choicechosen from the entire ACS portfolio).

    Related micropatterned microfluidics studies:

    1)https://www.nature.com/articles/s41578-020-00247-y

    Imaging systems and microfluidic devices for the in-depth and real-time investigation of viral structures and transmission,material platforms for organoids and organs-on-a-chip, in drug delivery and vaccination, and for the production of medical equipment.

    1. Z Tang†, N Kong†, X Zhang†, Y Liu, P Hu, S Mou, P Liljeström, J Shi, W Tan, J S Kim, Y Cao, R Langer, K W. Leong, O C. Farokhzad, W Tao. A materials-science perspective on tackling COVID-19. Nature Reviews Materials, 2020, 5, 847-860. (Featured Cover Paper, highly cited paper, accessed>19,000 times, Impact Factor:71.189)

     2)https://www.nature.com/articles/s41467-019-12462-5

    Dendronized fluorosurfactant for highly stable water-in-fluorinated oil emulsions with minimal inter-droplet transfer of small molecules

    1. M Chowdhury, W Zheng, S Kumari, J Heyman, X Zhang, P Dey, D Weitz, R Haag. Dendronized fluorosurfactants provide phenomenal droplet integrity to picolitre emulsions for therapeutics development. Nature Communications, 2019, 10, 4546 (Impact Factor:14.919).

    3) https://doi.org/10.1021/acsnano.0c02701

    An osmotic-pressure, pH, excretion, nutrition, gas, ionic-strength, flow-rate, and temperature (OPEN GIFT) microenvironment-controlled micropatterned microfluidic model (MMMM) for biomimetic in situ studies (BISS) in simulating the in vivo microenvironment to study in situ the stress applied to Giardia in the intestinal tract. 

    1. Y Wang, L Lu, G Zheng*, X Zhang*. Microenvironment-controlled micropatterned microfluidic model for biomimetic in-situ studies. ACS Nano, 2020, 14(8), 9861-9872. (Featured Cover Paper, Impact Factor:15.881).

    4) https://doi.org/10.1016/j.bios.2019.111597

    1. S Han†, Q Zhang†, X Zhang†, X Liu, L Lu, J Wei, Y Li, Y Wang, G A digital microfluidic diluter- based microalgal motion biosensor for marine pollution monitoring. Biosensors and Bioelectronics, 2019, 143, 111957 (Impact Factor:10.257).

    5)  https://doi.org/10.2144/btn-2019-0134 

    1. L Liu, N Xiang, Z Ni, X Huang, J Zheng, Y Wang, X Zhang*. Step Emulsification: High throughput production of monodisperse droplets. BioTechniques, 2020, 68 (3), 114-116. (Invited Expert Paper)

    6) https://doi.org/10.1016/j.nantod.2021.101152    https://authors.elsevier.com/a/1cv~x6DSyB6RP5

    1.  S Wang, Z Shen, Z Shen, Y Dong, Y Li, Y Cao, Y Zhang, S Guo, J Shuai, Y Yang, C Lin, M Guo, X Chen*, X Zhang*, Q Huang*. Machine-learning micropattern manufacturing. Nano Today, 2021, 38 (2021), 101152. (Impact Factor:20.722)

    7) https://doi.org/10.1016/j.bioactmat.2021.04.014

    1. Z Li†, X Zhang† J Ouyang, D Chu, F Han, L Shi, R Liu, Z Guo, G Gu, W Tao, L Jin, J Li. Ca2+-supplying black phosphorus-based scaffolds developed with microfluidic technology for osteogenesis. Bioactive materials, 2021, 6(11), 4053-4064. (Instant Impact Factor:14.093).         

    8) https://doi.org/10.1016/j.pmatsci.2020.100768 

    Microfluidic technology for Theranostics.

    1. J Yang†, X Zhang†, C Liu†, Z Wang, L Deng, C Feng, W Tao, X Xua, W Cui. Biologically Modified Nanoparticles as Theranostic Bionanomaterials. Progress in Materials Science, 2021, 118, 100768. (Impact Factor:39.58)

    9) https://doi.org/10.1007/s40820-021-00663-x

    1. M Chowdhury†, X Zhang, L Amini, A Faghani, A Singh, M Henneresse, R Haag. Functional Surfactants for Molecular Fishing, Capsule Creation, and Single-Cell Gene Expression.  Nano-Micro Letters, 2021, 13, 147. (Impact Factor:16.419)

     10) https://doi.org/10.1021/acs.analchem.1c00917

      1.  G Zheng, Q Gao, Y Jiang, L Lu, J Li,X Zhang, H Zhao, P Fan, Y Cui, F Gu, Y Wang.            Instrumentation-compact digital microfluidic (DMF) reaction interface extended  loop-mediated isothermal amplification (LAMP) for sample-to-answer testing of Vibrio parahaemolyticus. Analytical Chemistry, 2021, 93, 28, 9728–9736.

    11) https://doi.org/10.1016/j.marpolbul.2019.04.063  https://doi.org/10.1166/jnn.2019.16752   https://doi.org/10.1109/ICSENS.2010.5690979.

    1. Zhang, Q., Zhang, X., Zhang, X., Jiang, L., Yin, J., Zhang, P., Han, S., Wang, Y.& Zheng, G. A feedback-controlling digital microfluidic fluorimetric sensor device for simple and rapid detection of mercury (II) in costal seawater. Marine pollution bulletin, 2019, 144, 20-27.   https://doi.org/10.1016/j.marpolbul.2019.04.063
    2. R Yang, Z Gong, X Zhang, L Que. Single-walled carbon nanotubes (SWCNTs) and poly(3,4- ethylenedioxythiophene) nanocomposite microwire-based electronic biosensor fabricated  by  microlithography and layer-by-layer nanoassembly. Journal of Nanoscience and Nanotechnology, 2019,19(12), 7591-7595. https://doi.org/10.1166/jnn.2019.16752 

Dr. Xingcai Zhang, Harvard/MIT Research Fellow; Science Writer/Editorial (Advisory) Board Member for Springer Nature, Materials Today, Royal Society of Chemistry, Wiley; with 5 STEM degrees/strong background in sustainable Nature-derived/inspired/mimetic materials for biomed/sensing/catalysis/energy/environment applications, with more than 100 high-impact journal publications in Nature Reviews Materials, Nature Nanotechnology, Nature Medicine, etc. https://scholar.google.com/citations?hl=en&user=2vDraMoAAAAJ&view_op=list_works&sortby=pubdate

https://scholar.harvard.edu/xingcaizhang 

https://orcid.org/0000-0001-7114-1095

Contact: Dr. Xingcai Zhang xingcai@mit.edu  chemmike1984@gmail.com +1-2253041387 wechat:drtea1

Please sign in or register for FREE

If you are a registered user on Research Communities by Springer Nature, please sign in

Subscribe to the Topic

Biotechnology
Life Sciences > Biological Sciences > Biotechnology

Related Collections

With collections, you can get published faster and increase your visibility.

Applied Sciences

This collection highlights research and commentary in applied science. The range of topics is large, spanning all scientific disciplines, with the unifying factor being the goal to turn scientific knowledge into positive benefits for society.

Publishing Model: Open Access

Deadline: Ongoing