Polybiome Systems Medicine: Conceptual Architecture, Methodological Foundations, and Translational Applications — Volume I: Vision and Foundational Methodology
Published in Bioengineering & Biotechnology, Chemistry, and Research Data
I’m sharing the release of Polybiome Systems Medicine (PSM), Volume I, which focuses on the vision and foundational methodology of a systems-level approach to host–microbiome–inflammation interactions.
The aim is to move beyond fragmented views of the microbiome and toward a coherent architecture that integrates conceptual structure, methodological foundations, and translational thinking. This volume lays out the core framework, defines the guiding principles, and establishes the conceptual and terminological basis needed for consistent systems-level reasoning in this space.
PSM is designed to support:
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Integration of microbiome, immunometabolism, and inflammation at a systems level
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Methodological alignment with multi-omics and AI-assisted analysis
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Translational use cases in complex, chronic, and metabolic diseases
Rather than adding complexity, the goal is to provide a clearer structure for thinking, modeling, and communicating about biologically complex, network-driven phenomena.
The foundational report is available on Zenodo with a DOI and is intended as a reference point for future methodological and applied work within the PSM framework.
I welcome discussion, critique, and collaboration from colleagues working in systems medicine, microbiome research, and translational biology.
REYED, R. M. (2026). Polybiome Systems Medicine: Conceptual Architecture, Methodological Foundations, and Translational Applications — Volume I: Vision and Foundational Methodology (0.1). Zenodo. https://doi.org/10.5281/zenodo.18294835
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