Human induced pluripotent stem cells (iPSCs) have created new opportunities to deliver immune-cell therapies to patients who currently lack effective treatment options. iPSC platforms can provide a renewable, standardized supply of therapeutic immune cells with robust function, supporting indications that range from cancer and chronic viral infection to autoimmunity and transplantation-related complications. In this Thematic Series, four experts review the biology and translation of iPSC-derived iNKT cells for head and neck cancer, antigen-presenting cell products for cancer translational research, CD8+ T cells for cancer and HIV, and CD4+ regulatory T cells for autoimmunity and transplant immunology. Together, these articles highlight engineering and manufacturing challenges, safety and efficacy considerations, and emerging directions toward scalable, next-generation immunotherapies.

Please note that this Collection is invite-only and will not accept unsolicited submissions.

All submissions in this collection undergo the journal’s standard peer review process. Similarly, all manuscripts authored by a Guest Editor(s) will be handled by the Editor-in-Chief. As an open access publication, this journal levies an article processing fee (details here). We recognize that many key stakeholders may not have access to such resources and are committed to supporting participation in this issue wherever resources are a barrier. For more information about what support may be available, please visit OA funding and support, or email OAfundingpolicy@springernature.com or the Editor-in-Chief.

Inflammaging, defined as low-grade chronic inflammation that accompanies aging, gradually disrupts systemic homeostasis and underlies the onset of multiple age-related disorders. Recent advances have expanded this concept beyond cellular and molecular mechanisms, revealing complex interactions that encompass immune modulation, metabolic reprogramming, organ crosstalk, the gut environment, and even social and environmental determinants. This Collection aims to explore inflammaging from an integrative and multilayered perspective. We welcome studies that investigate the molecular basis of cellular and immune aging, systemic inflammatory networks, their impact on regeneration and tissue repair, and the interplay with environmental and lifestyle factors. Original research, reviews, and conceptual or perspective articles that advance the understanding of inflammaging across biological scales are all encouraged.

All submissions in this collection undergo the journal’s standard peer review process. Similarly, all manuscripts authored by a Guest Editor(s) will be handled by the Editor-in-Chief. As an open access publication, this journal levies an article processing fee (details here). We recognize that many key stakeholders may not have access to such resources and are committed to supporting participation in this issue wherever resources are a barrier. For more information about what support may be available, please visit OA funding and support, or email OAfundingpolicy@springernature.com or the Editor-in-Chief.