Recent Advances in Polyurethane Polymer for Biomedical Applications
Published in Bioengineering & Biotechnology and Law, Politics & International Studies
(https://pubs.acs.org/doi/full/10.1021/acs.molpharmaceut.5c00538)
Polyurethanes (PUs) are versatile polymers with tunable physicochemical, mechanical, and biological properties, and as such, making them highly suitable for a wide range of biomedical applications. Advances in polymerization techniques have enabled significant modifications to PU surfaces, thereby enhancing their functionality for diverse uses. This review discusses PU synthesis, chemistry, and surface modification strategies, and provides an overview of commercially available materials, patents, and biomedical applications, including coatings, implants, tissue engineering, drug delivery systems, and cardiovascular devices. It also highlights recent progress in PU-based biomaterials, focusing on biocompatibility, degradation processes, and emerging market trends. Although PUs have many advantages, some challenges remain, including problems with biodegradability, long-term biocompatibility, mechanical limitations, processing difficulties and surface degradation, bacterial development, colonization, and calcification in biomedical applications. With ongoing research into sustainable and biodegradable PU formulations, there is strong potential for polyurethane technology to play a transformative role in the next generation of medical innovations.
Innovative, passionate, enthusiastic goal-oriented scientific professional with extensive experience in formulation development and hands on experience in solving challenging innovation-based problems in pre-formulation, optimization, characterization, quality risk assessment, pharmaceutical quality management, Design of experiment. I actively collaborated with a multidisciplinary team of researchers, clinicians, and industry partners. Author of more than 50 publications in area of m-PEG-PLA micelles, PLGA nanoparticles, liposomes, inhalation product, Solid dispersion, Neutrophils nanovesicle, Lyophilized products, and LNPs that can deliver anticancer agents, immunostimulants, Antibody drug conjugates, and prodrugs to the target site, enhance their therapeutic efficacy, and reduce their systemic toxicity. I am a creative and versatile researcher with proven ability to solve complex problems related to cancer cell biology, drug delivery systems with production of cutting-edge nano formulations
In depth knowledge on analytical and polymer characterization and trouble shooting. Experienced in drafting and reviewing SOPs, BMRs, EHS inspection, IACUC protocols setting specifications for the products based on requirement. Enriched with application of QBD principles for drug product development, Risk assessment, manufacturing and process scale-up as per Regulatory requirements. Experienced with drug product testing in preclinical animal models.
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