The interplay between vascular mechanisms and headache, especially migraine, has long navigated through a sea of intricate and sometimes contradictory research findings, crafting a narrative that intertwines the serenity of clear connections with the tempest of unresolved queries. In this special collection, we cordially invite researchers and clinicians to sail with us into an exploration of "Vascular Triggers of Headache," in which we shall embark on a journey through the vasculature and its posited roles, shedding light on known territories and voyaging into the unexplored. The intricate tapestry of vascular causes associated with headache is rich, yet not fully unraveled. Migraine, an enigmatic and multifaceted neurological disorder, have historically been enshrouded in vascular theories, with early hypotheses anchoring its pathophysiology to cerebral vasodilation. Conversely, contemporary research has somewhat diverted from this stringent vascular focus, steering towards neuronal and neurovascular platforms. A divergence that inevitably sparks the debate: Is migraine predominantly a vascular disorder? We invite scholarly debates that weigh anchor in evidence and conjecture alike, providing a balanced scrutiny into this age-old question and its concomitant hypotheses. Comprehensive reviews that delve into vascular culprits such as cranial or cervical artery dissections, cerebral microemboli, patent foramen ovale (PFO), reversible cerebral vasoconstriction syndrome (RCVS), and other vasculopathies (both genetic and acquired) will serve to both illuminate and question our current understanding, unearthing new questions and pathways for exploration. Further, we welcome original research articles that puncture through the current membrane of knowledge regarding the vascular mechanisms and headache. Innovative methodologies, exploratory studies, and research that breeches into new channels of understanding are particularly encouraged. Through this article Collection, we endeavor to create a confluence of ideas, knowledge, and curiosity. While the vascular mechanisms underlying headache and migraine remain an enigma, enveloped in a fog of partial understanding, this compilation aims to gather a fleet of scientific minds to dispel the mist and navigate towards enlightenment.

This collection of articles results from the tight collaboration between the European Headache Federation (EHF) and its Official Journal, The Journal of Headache and Pain. EHF Digital EducationThe educational aim of EHF, its own School of Advanced Studies (EHF-SAS), provides for nurturing talented young researchers in the headache area. Each Meeting of the EHF-SAS ends its path with the preparation of a review on special topics to be submitted for regular peer-review. EHF provides economical support for the related APCs. In such way we think that the positive loop might be maintained and attract more and more young researchers. The activity of the EHF-SAS is academically based in Sapienza University of Rome, but its mission foresees also EHF-SAS Meetings hosted by the EHF Federated Societies in their own countries. This collection of articles has been sponsored by the EHF. Articles have undergone the journal's standard peer-review process overseen by the Editor-in-Chief.