Thermally reactive N-(2-hydroxypropyl)methacrylamide (HPMA) amphiphiles for drug solubilisation

Thermally active polymers, can respond structurally to temperature changes, making them interesting as potential drug delivery vehicles.

Published in Chemistry

Go to the profile of Ali Alsuraifi
Ali Alsuraifi
Assistant Professor , University of Basrah
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In this work, we synthesised amphiphilic APMA monomers using hydrophobic pendant groups via conjugation onto their primary amine group. The pendant groups chosen in this study were palmitoyl, dansyl and cholesteryl moieties. The amphiphilic monomers were subsequently copolymerized with N-(2-hydroxypropyl)methacrylamide (HPMA) using varied monomer feed ratios resulting in a thermo-responsive system. The ability of the resultant aggregates in aqueous solution to encapsulate and liberate model drugs (e.g., propofol, griseofulvin and prednisolone) was then determined.

Go to the profile of Ali Alsuraifi
Ali Alsuraifi
Assistant Professor , University of Basrah

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Pharmaceutics
Physical Sciences > Chemistry > Biological Chemistry > Pharmaceutics
Nanochemistry
Physical Sciences > Chemistry > Physical Chemistry > Nanochemistry
Medicinal Chemistry
Physical Sciences > Chemistry > Biological Chemistry > Medicinal Chemistry

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