WWP1 inhibition increases SHP2 inhibitor efficacy in colorectal cancer

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Hao Fan
Dr, Shanghai Changhai Hospital
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Nature
Nature Nature

WWP1 inhibition increases SHP2 inhibitor efficacy in colorectal cancer - npj Precision Oncology

npj Precision Oncology - WWP1 inhibition increases SHP2 inhibitor efficacy in colorectal cancer

The protein tyrosine phosphatase SHP2 plays a key role in activating RAS signaling, but its inhibitors are widely resistant in colorectal cancer (CRC). We reveal WWP1-PTEN-AKT signaling pathway is involved in the resistance of SHP2 inhibition. Combined inhibition of WWP1 and SHP2 exerts a synergistic lethal effect in CRC cells. Expression levels of WWP1 and SHP2 contribute to prognostic modeling in CRC patients. These findings may assist in individual clinical decision-making and clinical trial design, especially for patients with KRAS-mutant CRC.

Go to the profile of Hao Fan
Hao Fan
Dr, Shanghai Changhai Hospital

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Gastrointestinal Cancer
Life Sciences > Biological Sciences > Cancer Biology > Cancers > Gastrointestinal Cancer
Pharmacy
Life Sciences > Health Sciences > Pharmacy
Molecular Biology
Life Sciences > Biological Sciences > Molecular Biology

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