Go to the profile of Gang Wang

Gang Wang

PhD, Zhongnan Hospital of Wuhan university
  • China

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Communications Biology
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Mevalonate pathway inhibition reduces bladder cancer metastasis by modulating RhoB protein stability and integrin β1 localization

Activating the mevalonate (MVA) pathway increases bladder cancer (BLCA) spread. High MVA enzyme levels predict worse outcomes. Drugs like zoledronic acid or simvastatin blocking this pathway reduce cancer cell migration by affecting the protein RhoB. Targeting the MVA pathway could help treat BLCA.
Go to the profile of Gang Wang +3
Gang Wang and 3 others
Nov 09, 2024

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