About Liang Zhang
I have a cross-disciplinary educational background in both computer science and biology. In the past five years, my main work has been to use interdisciplinary technical means to study the mechanism of mitochondrial dysregulation in degenerative diseases at a cross-scale and the study of cell in situ spatial structure biology at near-atomic resolution. My team has published 14 research papers in top journals such as Cell Discovery, Nature Cell Biology, Nature Communications, Communications Biology, and Advanced Materials in the past five years. My interest has mainly focused on: 1) combining computer modeling, elucidating the important role of multiple post-translational modifications of mitochondrial ribosomes in mitochondrial function and cell homeostasis maintenance, as well as the molecular mechanisms of information communication and bidirectional regulation between mitochondria and the two organelles of the nucleus; 2) A novel fluorescent carbon dot specifically targeting RNA granules was synthesized from scratch and applied to electron microscopy imaging and fluorescence imaging, elucidating the material exchange process among multiple membraneless organelles within cells; 3) We comprehensively utilized synthetic chemistry, cell biology, and structural biology to systematically analyze the molecular mechanisms of tumor cell escape from T cell killing and negative regulation of PD-l immunotherapy.