Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Iron supplementation, diarrhea and the gut microbiome in children
Iron has been previously linked to diarrheal disease and adverse reprofiling of the gut microbiome in children in low- and middle-income countries. Results of this large randomized controlled study of children in Bangladesh provide further insight into these associations.
Deubiquitylase USP52 Promotes Bladder Cancer Progression by Modulating Ferroptosis through Stabilizing SLC7A11/xCT
We identified USP52 as a DUB that cleaves K48-linked ubiquitin at K4 and K12 of xCT. Loss of USP52 reduces cell proliferation by decreasing xCT and enhancing ferroptosis sensitivity. Combining USP52 depletion with IKE strongly inhibits BLCA progression, presenting a new potential therapy.
DNA polymerase POLD1 promotes proliferation and metastasis of bladder cancer by stabilizing MYC
Based on the bladder cancer (BLCA) pedigree containing germline mutation of POLD1 found in our last study, we further analyzed the molecular role of POLD1 driving tumorigenesis. We identified POLD1 as a promotor of BLCA via a MYC driven mechanism.
Behind the Scenes of the "Quality of Life and Social Change" Handbook
This handbook offers a holistic roadmap to improve individual and collective well-being. Rooted in the POZE paradigm, it explores the interconnectedness of individuals, communities, and the planet, offering practical insights for fostering sustainable, meaningful social change.
