Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Mapping the European Patent Landscape for Medical Uses of Known Products
European Patent Office (EPO) data show an increasing number of patents for new medical uses of known products
The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective cytotoxic activity in neuroblastoma
Our recent study revealed that the chemotherapeutic CX-5461 primarily binds and inhibits TOP2B, exhibiting selective cytotoxicity in neuroblastoma cells, which overexpress TOP2B. As such, pharmacological targeting of TOP2B raises safety concerns due to off-target drug interactions with this gene.