Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Isolation of a Ru(IV) side-on peroxo intermediate as a missing link in the water oxidation reaction
Obtaining information after a rate determining step (RDS) of a chemical reaction is difficult but essential for its understanding. Now, a Ru(IV) side-on peroxo complex has been isolated after the RDS − the O-O bond formation- in the water oxidation reaction allowing to track the reaction.
The story of walking on a resistant trail: TRAIL-resistance in GBM
Cingöz et al. Generation of TRAIL-resistant cell line models reveals distinct adaptive mechanisms for acquired resistance and re-sensitization. Oncogene, 2021.
https://www.nature.com/articles/s41388-021-01697-6
Ready-made CAR-T cells redirected against T cell malignancies
Base editing applied to human T cells