Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Behind the Paper: How IL-6 shapes the anti-tumor battle and supports TGFβ immune modulatory vaccines in pancreatic cancer
The study highlights that the antitumor efficacy of TGFβ-specific T cells in pancreatic cancer critically depends on IL-6 signaling. IL-6R blockade compromises the immune response by reducing vaccine-induced T-cell infiltration as well as increasing immunosuppressive tumor-associated macrophages.
How bad cholesterol is removed from blood
Cardiovascular disease is the number one cause of human mortality. New structural information helps to develop future therapeutic interventions for this chronic, human health problem.
Soil fungi remain active during drought
Drought significantly affects terrestrial ecosystems, including soil microbial communities. Our study, utilizing an innovative stable isotope tracing method, reveals that while bacterial growth was greatly reduced during drought, fungi maintained stable growth.
TSLPR CAR T-cell therapy: A new hope for CRLF2+ ALL, but timing of JAK inhibition is crucial
Acute lymphoblastic leukemia (ALL) with CRLF2 rearrangements in Ph-like and Down syndrome-associated ALL subtypes poses a significant challenge in pediatric oncology. These genetic abnormalities lead to constitutive signaling activation and induce resistance to conventional chemotherapy.
Stabilization of a cyclic network of strings by nodal control
For a network of coupled strings that contains a cycle, we show that boundary feedback stabilization that uses only data of the state at boundary nodes that are not contained in the cycle is in general impossible.
A Dirichlet actuator within the cycle yields exponential stability.
The story of plasmonic-catalytic 2D supercrystals for H2 generation
Novel photocatalysts result from the synergy between plasmonic and catalytic metals. Understanding their underlying operating principles is necessary and we provide solid evidence on the major role of the intense electric fields when energising the catalytic centers using 2D supercrystals
Generating synthetic medical data improves clinical applications
The scarcity of high-quality medical imaging datasets can be addressed by generative AI.
