Bioengineered Articular Cartilage Biomimetic Organ-on-a-Chip Using Microfluidics

Proud to share our recent published work exploring how microfluidics-based organ-on-a-chip (OOAC) technology can recreate the structural, biochemical, and mechanical environment of native articular cartilage.

Published in Research Data and Biomedical Research

Go to the profile of Upasna Upadhyay
Upasna Upadhyay
Research Scientist, KL University and GMERF
Bioengineered Articular Cartilage Biomimetic Organ-on-a-Chip Using Microfluidics
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Explore the Research

Nature
Nature Nature

Bioengineered articular cartilage biomimetic organ-on-a-chip using microfluidics - npj Biomedical Innovations

npj Biomedical Innovations - Bioengineered articular cartilage biomimetic organ-on-a-chip using microfluidics

Highlights of our work

  • Developed a decellularized extracellular matrix (dECM)–based bioink supporting chondrogenesis.

  • Optimized composite alginate–chitosan hydrogels achieving compression modulus of 0.18 MPa and tensile strength of 0.4 MPa.

  • Dynamic microfluidic perfusion (150 mbar & 50 mbar) enabled formation of superficial and middle cartilage zones.

  • MSCs-derived chondrocytes in bioink showed upregulation of COL2A1, Aggrecan, and Laminin — hallmark features of hyaline cartilage.

  • The resulting constructs exhibited non-linear mechanical behavior similar to native cartilage, positioning them as models for drug testing.

This study represents a step forward in tissue-engineered biomimetics, integrating material science, stem cell biology, and microfluidic mechanics to emulate native cartilage physiology in vitro.

Go to the profile of Upasna Upadhyay
Upasna Upadhyay
Research Scientist, KL University and GMERF

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