Blood pressure control with active ultrafiltration measures and without antihypertensives is essential for survival in hemodiafiltration and hemodialysis programs for patients with CKD. A prospective observational study.
Published in Social Sciences, General & Internal Medicine, and Pharmacy & Pharmacology
The main finding confirms the hypothesis of the study that there is more remarkable survival in the group of patients with CKD whose hypertension can be controlled without antihypertensive treatment and with the use of constant dry weight reduction measures to optimize ultrafiltration. The factors associated with the lack of control of arterial hypertension were a history of vascular amputation, a history of being an ex-smoker, being a carrier of type 2 diabetes mellitus, having a serum ferritin level greater than 26.75%, being male, and being treated with hemodialysis. The associated protective factors were having a diagnosis of glomerulonephritis as an etiology of chronic kidney disease, a history of never smoking, a serum ALB concentration greater than 4.214 g/dl, effective blood flow greater than 423.5 ml/min, and interdialytic weight gain >4.925%, hemodiafiltration as treatment, urea levels less than 103.78 mg/dl, and fasting glucose levels less than 109.2 mg/dl. According to the time-adjusted model, only four factors were associated: age, transferrin saturation, serum albumin levels, and history of vascular amputation.
In the stratified analysis, differences in survival were demonstrated by the percentiles of blood pressure taken in the last month of survival or censoring. With blood pressures ranging from 141 mmHg to 122 mmHg, there is a proportional risk of death associated with the intake of antihypertensive agents. The same occurs when the blood pressure is less than 105 mmHg. These relationships could not be established with pressures greater than 141 mmHg.
Follow the Topic
-
BMC Nephrology
This is an open access journal publishing original peer-reviewed research articles in all aspects of the prevention, diagnosis and management of kidney and associated disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
Your space to connect: The Cancer in understudied populations Hub
A new Communities’ space to connect, collaborate, and explore research on Cancers, Race and Ethnicity Studies and Mortality and Longevity!
Continue reading announcementRelated Collections
With Collections, you can get published faster and increase your visibility.
Vascular control and renal blood flow regulation
BMC Nephrology is calling for submissions to our Collection on Vascular control and renal blood flow regulation.
This Collection aims to explore the intricate relationships between vascular control and renal blood flow regulation, highlighting current research and advancements in this critical area.
Advances in the field have significantly enhanced our understanding of renal vascular dynamics and their implications for various kidney disorders, such as hypertension, chronic kidney disease, and acute kidney injury. Recent studies have focused on the molecular pathways involved in renal perfusion regulation, including the role of nitric oxide, prostaglandins, and endothelial function. By unraveling these complex interactions, researchers have begun to develop novel therapeutic strategies aimed at improving renal blood flow and preventing renal injury, thereby enhancing patient outcomes.
Future research in this domain holds promise for identifying new biomarkers and therapeutic targets that can lead to more effective interventions for renal diseases. As our understanding of renal circulation deepens, it is likely that innovative approaches will emerge, such as personalized medicine strategies that account for individual variations in renal vascular responses. Additionally, advancements in imaging techniques and computational modeling may provide unprecedented insights into renal blood flow regulation, facilitating better clinical decision-making.
Topics of interest include, but are not limited to:
Mechanisms of renal blood flow regulation
Impact of renal vascular dynamics on kidney disease
Role of endothelial function in renal perfusion
Advances in renal circulation imaging
This Collection supports and amplifies research related to SDG 3 (Good Health and Well-being).
All manuscripts submitted to this journal, including those submitted to collections and special issues, are assessed in line with our editorial policies and the journal’s peer review process. Reviewers and editors are required to declare competing interests and can be excluded from the peer review process if a competing interest exists.
Publishing Model: Open Access
Deadline: Mar 19, 2026
Novel therapies for glomerular diseases
BMC Nephrology invites submissions to our Collection on Novel therapies for glomerular diseases.
Glomerular diseases encompass a diverse group of disorders that affect the kidney's filtering units, leading to significant morbidity and mortality. These conditions, which include focal segmental glomerulosclerosis, minimal change disease, and IgA nephropathy, have traditionally posed challenges in terms of effective treatment options. Recent advancements in our understanding of the underlying pathophysiology and the introduction of novel therapeutic modalities, such as targeted biologics and small molecules, present new avenues for intervention. This Collection invites contributions that explore these innovative therapies and their potential to transform the management of glomerular diseases.
Advances in clinical research have led to promising developments, including the successful completion of several clinical trials that evaluate the efficacy of new agents. These therapies not only aim to improve patient outcomes but also focus on personalized treatment approaches that consider individual patient characteristics. By fostering collaboration among researchers, clinicians, and industry partners, we can enhance our understanding and management of these complex conditions. Continued research in this field has the potential to yield groundbreaking discoveries that could redefine treatment paradigms for glomerular diseases.
Topics of interest for this Collection include, but are not limited to:
Novel therapeutic agents in glomerular diseases
Clinical trials of innovative treatments
Impact of new therapies on patient outcomes
Personalized treatment approaches for glomerular disorders
This Collection supports and amplifies research related to SDG 3: Good Health and Well-being and SDG 9: Industry, Innovation, and Infrastructure.
All manuscripts submitted to this journal, including those submitted to collections and special issues, are assessed in line with our editorial policies and the journal’s peer review process. Reviewers and editors are required to declare competing interests and can be excluded from the peer review process if a competing interest exists.
Publishing Model: Open Access
Deadline: Jun 30, 2026
Please sign in or register for FREE
If you are a registered user on Research Communities by Springer Nature, please sign in