Chemistry-driven processes are essential inspirations for researchers to design biomaterials applied as promising diagnostic tools, therapeutic solutions or tissue substitutes, etc. To increase the understanding of material chemistry in biomedical applications, this topical collection focuses on documenting the chemistry covering nanoscale to macroscale biomaterials, including surface science and interactions with the body at the molecular level. We seek articles that highlight the principles of material chemistry or approaches to investigate and improve the material properties in biomedical research. The material properties here mainly include biocompatibility, physical, chemical, mechanical, and other particular properties required for medical and dental materials. Reviews, original research, and commentaries are all welcomed.

Keywords: Material chemistry, surface science, nanotechnology, biocompatibility, physical and chemical property, mechanical property, biomedical application.

Material chemistry has a long-standing history and has been extensively exploited in a wide range of life science research such as biological, chemical, and environmental engineering. The invention of novel materials for biological applications has led to the creation of biomaterials for tissue engineering, nanomaterials for drug delivery, and smart materials that interact dynamically with biological systems. These advances have significantly revolutionized the fields of healthcare including medical treatments, diagnostics, and biological studies. In recent years, the synergy between material chemistry and life sciences has been particularly evident in the development of materials that enable precision medicine, improve the accuracy of diagnosis, and facilitate regeneration of defected tissues. In particular, nanoparticles engineered for targeted drug delivery have significantly enhanced the efficacy of treatments while minimizing side effects, and responsive biomaterials have opened new avenues for developing adaptive therapeutic devices. The application of these advanced materials in life science not only enhances our understanding of biological processes but also paves the way for innovative solutions to pressing healthcare challenges. This topical collection aims to cover papers that explore the intersection of material chemistry and life sciences, focusing on the design, synthesis, and application of advanced materials in biological contexts. Translational advances in material chemistry for healthcare, biotechnology, and environmental sustainability will be highlighted in this topical collection, reflecting the multidisciplinary nature of this rapidly evolving field.

Keywords: Material chemistry, life science, biomaterials, smart materials, drug delivery, nanomaterials, medicinal chemistry.