As hydrogel applications expand in bioengineering, drug delivery, wound healing and wearable devices, their strong swelling and uncontrollable degradation severely restrict long-term performance. Now, researchers from the State Key Laboratory of Supramolecular Structure and Materials at Jilin University, led by Professor Yunfeng Li, have presented a nanocolloidal hydrogel (NCG) that remains dimensionally stable and resists biodegradation for over six months. This work offers a clinically translatable platform that overcomes the swelling-driven failures of conventional hydrogels.

Why Nonswelling Hydrogels Matter

• Dimensional Stability: NCGs exhibit a volume swelling ratio of ≈1.0 for 200 days in PBS (10–100 mM, 4–37 °C), eliminating tissue compression or implant migration.
• Biodegradation Resistance: In vitro hyaluronidase exposure and in vivo mouse implantation show no macroscopic degradation for 24 weeks, extending implant lifetime.
• Super-Lubrication: A coefficient of friction as low as ~0.0018 reduces wear at tissue–device interfaces.

Innovative Design and Features

• Nanoparticle Building Blocks: Methacryloyl-hyaluronate (HAMA) nanoparticles (≈26 nm) self-assemble into hydrophobic nanodomains (radius ≈1 nm) that prevent water uptake.
• Photocrosslinked Network: UV-triggered polymerization interconnects nanoparticles while preserving internal hydrophobic phases, yielding transparent, mechanically tunable gels.
• Universal Composition: Strategy extended to methacryloyl-gelatin and binary HAMA/gelatin NCGs, maintaining nonswelling behavior.

Applications and Future Outlook

• Long-Term Drug Delivery: Stable permeability and hydrophobic reservoirs enable sustained, zero-order release without dose dumping.
• Soft-Tissue Augmentation: Storage modulus (2–11 kPa) matched to cartilage, skin and vasculature; supports 3D cell culture with >90 % viability.
• Implantable Bioelectronics: Low-friction, transparent coating protects sensors from fibrous encapsulation while minimizing tissue irritation.
• Challenges and Opportunities: Scale-up of nanoparticle synthesis, regulatory qualification of methacryloyl-modified biopolymers, and large-animal validation are next steps toward clinical translation.

This comprehensive study provides a blueprint for engineering next-generation hydrogels that combine long-term structural integrity with biofunctionality. It underscores the importance of nanoscale hydrophobic engineering in overcoming the classic swelling–degradation trade-off. Stay tuned for more translational advances from Professor Yunfeng Li’s group at Jilin University!