Skin-Inspired Ultra-Linear Flexible Iontronic Pressure Sensors for Wearable Musculoskeletal Monitoring

Skin-Inspired Ultra-Linear Flexible Iontronic Pressure Sensors for Wearable Musculoskeletal Monitoring
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Skin-Inspired Ultra-Linear Flexible Iontronic Pressure Sensors for Wearable Musculoskeletal Monitoring - Nano-Micro Letters

The growing prevalence of exercise-induced tibial stress fractures demands wearable sensors capable of monitoring dynamic musculoskeletal loads with medical-grade precision. While flexible pressure-sensing insoles show clinical potential, their development has been hindered by the intrinsic trade-off between high sensitivity and full-range linearity (R2 > 0.99 up to 1 MPa) in conventional designs. Inspired by the tactile sensing mechanism of human skin, where dermal stratification enables wide-range pressure adaptation and ion-channel-regulated signaling maintains linear electrical responses, we developed a dual-mechanism flexible iontronic pressure sensor (FIPS). This innovative design synergistically combines two bioinspired components: interdigitated fabric microstructures enabling pressure-proportional contact area expansion (∝ P1/3) and iontronic film facilitating self-adaptive ion concentration modulation (∝ P2/3), which together generate a linear capacitance-pressure response (C ∝ P). The FIPS achieves breakthrough performance: 242 kPa−1 sensitivity with 0.997 linearity across 0–1 MPa, yielding a record linear sensing factor (LSF = 242,000). The design is validated across various substrates and ionic materials, demonstrating its versatility. Finally, the FIPS-driven design enables a smart insole demonstrating 1.8% error in tibial load assessment during gait analysis, outperforming nonlinear counterparts (6.5% error) in early fracture-risk prediction. The biomimetic design framework establishes a universal approach for developing high-performance linear sensors, establishing generalized principles for medical-grade wearable devices. Graphical Abstract

As wearable health monitoring advances, the demand for flexible pressure sensors that combine high sensitivity, full-range linearity, and medical-grade accuracy continues to grow. Now, researchers from the Chongqing Institute of Green and Intelligent Technology, led by Prof. Chao Zhang and Prof. Jun Yang, have developed a bioinspired dual-mechanism iontronic pressure sensor (FIPS) that mimics human skin structure—achieving record-breaking linearity and sensitivity for real-time musculoskeletal load monitoring.

Why This Sensor Matters

  • Ultra-Linear Response: Maintains R2> 0.997 across 0–1 MPa, overcoming the typical trade-off between sensitivity and linearity in flexible sensors.
  • Medical-Grade Accuracy: Achieves 1.8% error in ground reaction force (GRF) estimation—far superior to nonlinear sensors (6.5% error).
  • Scalable & Stable: Demonstrates excellent reproducibility, long-term stability, and scalability for smart insole integration.

Innovative Design and Features

  • Dual-Mechanism Sensing: Combines contact area expansion (∝P1/3) and ion concentration modulation (∝P2/3) to produce a linear capacitance-pressure response (C ∝P).
  • Skin-Inspired Structure: Uses woven iontronic fabric embedded in a polyurethane matrix, mimicking the dermal collagen-elastic fiber network for wide-range mechanical adaptability.
  • High LSF: Achieves a linear sensing factor (LSF) of 242,000—the highest reported to date for flexible pressure sensors.

Applications and Performance

  • Smart Insole Integration: Enables real-time tibial load monitoring during walking and running on various terrains (concrete, track, lawn).
  • Gait Analysis: Accurately classifies walking speeds with ~100% accuracy and predicts tibial stress with high precision.
  • Durability: Withstands >10,000 loading cycles and maintains stable performance under bending, humidity, and temperature variation.

Conclusion and Outlook

This work introduces a universal design paradigm for high-performance linear flexible sensors, bridging the gap between biological inspiration and engineering precision. The FIPS platform opens new avenues for wearable biomechanics, sports medicine, and rehabilitation robotics, offering a transformative tool for early fracture-risk prediction and personalized musculoskeletal health monitoring.

Stay tuned for more innovations from Prof. Chao Zhang and Prof. Jun Yang’s team at the Chongqing Institute of Green and Intelligent Technology!

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Sensors and Biosensors
Physical Sciences > Materials Science > Materials for Devices > Sensors and Biosensors
Bioinspired Materials
Physical Sciences > Materials Science > Soft Materials > Bioinspired Materials
Wearable Technology
Technology and Engineering > Biological and Physical Engineering > Biomedical Engineering and Bioengineering > Biomedical Devices and Instrumentation > Wearable Technology
Materials for Devices
Physical Sciences > Materials Science > Materials for Devices
  • Nano-Micro Letters Nano-Micro Letters

    Nano-Micro Letters is a peer-reviewed, international, interdisciplinary and open-access journal that focus on science, experiments, engineering, technologies and applications of nano- or microscale structure and system in physics, chemistry, biology, material science, and pharmacy.