Food systems are undergoing transformations driven by the need to ensure global food security, protect human health, and reduce negative environmental impact. The emergence of novel food sources, advanced processing technologies, and the global shift towards sustainable diets bring forward unprecedented opportunities for improving nutrition and environmental outcomes. However, these innovations also introduce complex trade-offs between nutritional benefits, food safety risks, environmental sustainability, socio-economic factors, and consumer acceptance.

Risk-Benefit Analysis (RBA) offers a structured framework for evaluating such trade-offs by assessing the potential health risks and benefits associated with foods, ingredients, or technologies. An effective RBA framework encompasses three essential pillars:

1. Risk-Benefit Assessment – The scientific evaluation of both adverse and beneficial health effects.

2. Risk-Benefit Management – The formulation of strategies to mitigate risks while optimizing benefits.

3. Risk-Benefit Communication – Transparent dissemination of outcomes to regulators, stakeholders, and the public.

Nevertheless, contemporary food system challenges extend beyond human health impacts alone. Environmental pressures, socio-economic inequalities, ethical considerations, and sustainability goals all intersect with food safety and nutrition. To address these multi-dimensional factors, it is essential to evolve RBA towards an integrated, systems-thinking approach.

Multi-Criteria Decision Analysis (MCDA) provides a methodology to evaluate and balance multiple, often conflicting criteria, such as health, safety, sustainability, economic viability, and societal acceptance. Coupling RBA with MCDA enables decision-makers to navigate these complexities, supporting balanced and evidence-informed strategies in food innovation, regulation, and policy development. Furthermore, applying a One Health approach, which recognizes the intrinsic interconnections between human, animal, and environmental health, enhances the systemic robustness of RBA-MCDA frameworks. Integrating One Health principles ensures that risk-benefit evaluations consider broader ecosystem dynamics, including zoonotic risks, antimicrobial resistance, and biodiversity impacts, thereby aligning with global sustainability and public health objectives.

Aim of the Special Issue

This Special Issue aims to bring together multidisciplinary research advancing holistic Risk-Benefit Analysis and Multi-Criteria Decision Analysis methodologies, which are essential for addressing the intersecting challenges of nutrition, food safety, sustainability, and One Health in next-generation food systems. We invite contributions that integrate perspectives from nutritional science, food safety (chemical, microbial, and allergenic), environmental sciences, socio-economic analysis, and policy frameworks. We particularly encourage studies that:

-Present methodological innovations enhancing the integration of health, environmental, and socio-economic considerations in RBA.

-Demonstrate real-world applications of RBA-MCDA in the context of novel foods, sustainable diets, and emerging food technologies.

-Contribute to the development of decision-support tools and policy-relevant frameworks fostering resilient, safe, nutritious, and sustainable food environments.

Key Topics of Interest

Methodological advances in RBA and MCDA

-Development of advanced RBA frameworks integrating dietary health and food safety (chemical, microbial, allergenicity risks)

-Application of MCDA to balance health outcomes, safety, environmental sustainability, and socio-economic criteria.

-Integration of digital twins, AI-driven predictive models, and real-time analytics in dynamic food risk-benefit assessments.

-Methodologies for incorporating long-term health outcomes, environmental impact metrics, and consumer behaviour dynamics into RBA models.

Using RBA and MCDA for novel foods & emerging technologies

-Risk-Benefit and MCDA assessments of cell culture-derived foods, precision fermentation-derived ingredients, and other novel dietary sources.

-Evaluating functional foods, bioactive compounds, and fortified products through integrative RBA-MCDA approaches.

-Addressing safety-sustainability trade-offs in circular food systems and food waste valorisation initiatives.

Sustainable diets and food processing innovations

-Scenario modeling of sustainable dietary patterns (e.g., EAT-Lancet diet, flexitarian diets) and their cumulative health and safety impacts.

-Holistic evaluation of emerging food processing technologies (e.g., high-pressure processing, cold plasma, pulsed light) from a risk-benefit perspective.

-Integrated assessments of complex food matrices, accounting for nutrient-contaminant interactions and processing effects.

Systemic challenges, One health, and policy dimensions

-Operationalizing One Health frameworks within RBA-MCDA to assess food safety risks at the human-animal-environment interface (e.g., antimicrobial resistance, zoonoses, ecosystem impacts).

-Evaluating the compounded impacts of climate change, geopolitical instability, and global food supply chain vulnerabilities on food safety and nutritional risks.

-Development of RBA-informed policy frameworks for regulatory decision-making, dietary guidelines, and sustainable food governance.

-Advancing risk communication strategies, stakeholder engagement models, and methodologies to address equity and socio-economic disparities in RBA and MCDA.

All submissions in this collection undergo the journal’s standard peer review process. Similarly, all manuscripts authored by a Guest Editor(s) will be handled by the Editor-in-Chief. As an open access publication, this journal levies an article processing fee (details here). We recognize that many key stakeholders may not have access to such resources and are committed to supporting participation in this issue wherever resources are a barrier. For more information about what support may be available, please visit OA funding and support, or email OAfundingpolicy@springernature.com or the Editor-in-Chief.

This special issue of the Food Safety and Risk Journal will highlight selected cutting-edge research and innovation outcomes presented at the 3rd EU Food Safety Forum, held on 2–3 December 2025 in Rome, Italy. Organized by the EU Food Safety Platform, the Forum will gather multidisciplinary experts to share scientific advances addressing the evolving challenges of food safety within the bioeconomy and competitiveness context.

The special issue will collect applied research results as well as forward looking studies that:

- Explore novel bioeconomy-driven approaches to enhance food safety and sustainability, including alternative proteins, circularity, and emerging food technologies.

- Present advancements in analytical methods, risk assessment approaches, and safety management tools that improve detection, traceability, and control of food safety hazards and food frauds.

- Showcase the role of artificial intelligence (AI) and digitalization in transforming food safety monitoring, data integration, predictive risk modeling, decision support systems, communication.

- Feature social innovation initiatives and research focused on effective communication, consumer engagement, and dissemination of food safety information to citizens, empowering informed choices and fostering public trust.

- Include forward-looking contributions by young researchers and innovators, introducing new perspectives and fresh ideas in tackling food safety challenges

By compiling these diverse research outputs, this special issue aims to advance scientific understanding and innovative applications that strengthen the safety, resilience, and competitiveness of European food systems.

Contributions are encouraged by Forum participants and EU Food Safety Platform members (subscribers). This collection is for EU Food Safety Platform community only. Please register on the platform before submitting to the collection. For more information, click here.

“Members” are those who sign the ToR, while “community” refers to all registered users.

All submissions in this collection undergo the journal’s standard peer review process. Similarly, all manuscripts authored by a Guest Editor(s) will be handled by the Editor-in-Chief. As an open access publication, this journal levies an article processing fee (details here). We recognize that many key stakeholders may not have access to such resources and are committed to supporting participation in this issue wherever resources are a barrier. For more information about what support may be available, please visit OA funding and support, or email OAfundingpolicy@springernature.com or the Editor-in-Chief.