In late 2020 the COVID-19 vaccination rollout in England comprised two key recommendations: (i) prioritise elderly & vulnerable; (ii) interval between first & second doses increased from 3 to 12 weeks. We re-examined these recommendations with a mathematical model of SARS-CoV-2 infection in England.
As the COVID-19 pandemic continues there is an ever-present risk of more variants of concern (VOCs) arising. These VOCs may have beneficial mutations aiding their spread. We used three mathematical models to examine the potential drivers of SARS-CoV-2 VOC epidemics in England.