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Recent Comments
Very outstanding and thought-provoking study! It sheds new light on the role of TRIM28 in shaping lifelong cancer susceptibility through early-life epigenetic programming. The authors did a remarkable job integrating developmental biology, cancer genetics, and epigenomics using a cleverly designed mouse model that captures intrinsic developmental heterogeneity in a way that feels both biologically meaningful and experimentally elegant. The finding that genetically identical mice can diverge into distinct cancer risk states based on early stochastic epigenetic events is not only conceptually novel but also opens up exciting possibilities for understanding individual variation in cancer risk beyond genetics. The use of multi-omics profiling, combined with solid validation in human cancer datasets, gives the work strong translational relevance. Overall, this paper is not just rigorous, but also creative, and truly advances our understanding of how early-life biology can set the stage for disease decades later.