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ICGC-TCGA Pan-Cancer Analysis of Whole Genomes Project (PCAWG)

An international team has completed the most comprehensive study of whole cancer genomes to date, significantly improving our fundamental understanding of cancer and signposting new directions for its diagnosis and treatment.
Published in Cancer
Go to the profile of Jennifer Jennings
Jennifer Jennings
Senior Project Manager, Ontario Institute for Cancer Research
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Nature
Nature Nature

Pan-cancer analysis of whole genomes - Nature

The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Project (PCAWG), known as the Pan-Cancer Project, a collaboration involving more than 1,300 scientists and clinicians from 37 countries, analyzed more than 2,600 genomes of 38 different tumour types, creating a huge resource of primary cancer genomes. This was then the launch-point for 16 working groups studying multiple aspects of cancer’s development, causation, progression and classification.

The Pan-Cancer Project defined similarities and differences between cancer types. Based on this information, the next project of the ICGC is addressing key clinical questions to Accelerate Research in Genomic Oncology (The ARGO Project). You can read more about the ICGC-ARGO project at www.icgc-argo.org.

Go to the profile of Jennifer Jennings
Jennifer Jennings
Senior Project Manager, Ontario Institute for Cancer Research

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