Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Tumor-promoting immune cells retrained to fight most aggressive type of brain cancer
Glioblastomas (GBM) are frequently resistant to immunotherapy. We showed that targeting regulatory T cells (Tregs) with an agonistic anti-GITR antibody reprograms tumor-infiltrating Tregs to effector cells, overcoming response to PD1 blockade in preclinical models of GBM.
Overcoming cancer drug resistance by blocking the production of mitochondrial ATP that fuels drug efflux pumps
The presence of drug efflux pumps that prevent drug accumulation in chemoresistant cancer cells is a cause of cancer treatment failure. We show that these drug pumps need mitochondrial ATP as fuel and that blocking mitochondrial ATP production with novel MCJ mimetics overcomes cancer chemoresistance
Behind the manuscript AL amyloidosis
1 of the major un met need for patients with amyloidosis is earlier diagnosis. Currently 30% of patients succumb to the disease within the 1st year following diagnosis. This is because the diagnosis is delayed due to failure recognize.
