Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
EGF-SNX3-EGFR axis drives tumor progression and metastasis in triple-negative breast cancers
Sorting Nexin 3 (SNX3), a member of the recycling retromer complex, is a critical player in the epidermal growth factor (EGF) stimulated EGFR network in triple-negative breast cancers.
A negative NKX2-1/DUSP6/ERK signal inhibits lung cancer
Lung cancer is the #1 cancer killer in the U.S. Lung cancer’s heterogenous pathology and complicated oncogenic signaling networks have impeded care.
Higher Bleeding Rates Found with Direct Oral Anticoagulants in Myeloproliferative Neoplasm Patients
In this study we evaluated thrombosis and bleeding outcomes in myeloproliferative neoplasm (MPN) patients treated with direct oral anticoagulants (DOACs). We found an unexpected high cumulative incidence of bleeding, emphasizing the need for continued rigorous evaluation of DOACs in MPNs.
Detection of fluorine in absorption in a star-forming galaxy at redshift 4.4
Fluorine is a fascinating element in many ways. We report the detection of fluorine (in the form of hydrogen fluoride) in a lensed galaxy at z=4.4, seen as it was 1.3 billion years after the Big Bang. This detection may give valuable clues to the highly debated formation conditions of this element.
Challenge-oriented design of nanoagent enabling dual-mitochondrial-damage synergistic antitumor therapy
We developed a new type of MOFs-based core-shell nanoagents that enables near infrared (NIR) light-triggered two distinct antitumor mechanisms, namely oxidative stress and calcium overload, with both of them contributing to the mitochondria-dysfunction-associated eradication of tumor cells.
