Behind the Paper

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Filtered by: Chemistry
Communications Chemistry
Behind the Paper

Photoreactive fragment pharmacophores explore potential binding sites and provide hits for highly challenging drug targets

Photoaffinity-tagged fragments are increasingly used for convenient hit detection and binding site mapping in early drug discovery. We tackled two important challenges by maximizing the pharmacophore diversity of the core fragments, and by enhancing the labelling efficiency of the photoaffinity tag.
Go to the profile of David Bajusz +1
David Bajusz and 1 other
Sep 11, 2024

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