Evolutionary Studies Drive the Elucidation of Plant Natural Product Biosynthetic Pathways
Plant natural products are a major source of pharmaceuticals, with over one-third of FDA-approved drugs derived from natural products and their derivatives.
Iridium nitrenoid-enabled arene C−H functionalization
Direct arene C−H functionalization via nucleophilic aromatic substitution remains a challenging task. Here we report an iridium nitrenoid-catalysed arene C−H functionalization strategy, making use of readily available aryl azides as electrophiles to react with different nucleophiles.
