Prying into biomolecular condensates using single-droplet surface-enhanced Raman spectroscopy
We introduce a highly sensitive methodology that captures key vibrational signatures using surface-engineered, plasmonic, metal nanoparticles spontaneously encapsulated into protein liquid droplets allowing us to unveil the inner workings of biomolecular condensates in a droplet-by-droplet manner.
Exploiting the temporal dimension of hydrogen-deuterium exchange mass-spectrometry to localise protein-protein interactions
Our paper describes a method to more accurately extract structural information about protein-protein interactions from hydrogen-deuterium exchange mass spectrometry (HDX-MS).
Highly conducting single-molecule topological insulators based on mono- and di-radical cations
Designing long and highly conducting molecular wires has been a great challenge for decades. It has now been shown that an oxidized 2.6-nm-long oligophenylene-bridged bis(triarylamine) can show a single-molecule junction conductance over 0.1G0.
Synthesis of Aryldifluoromethyl Aryl Ethers via Nickel-Catalyzed Suzuki Cross-Coupling Reactions
An efficient synthesis of aryldifluoromethyl aryl ethers was established via nickel-catalyzed aryloxydifluoromethylation. Using this protocol, difluoromethylated PD-1/PD-L1 immune checkpoint inhibitors were comveniently achieved with enhanced antitumor efficacy over the non-fluoro congeners.
