Nanoscale iron catalysts for scalable and selective deuteration of (hetero)arenes
We have developed a general methodology for heterogeneous iron-catalysed deuteration reactions. The catalytic system is effective for selective deuteration of anilines, indoles, phenols, and other heterocyclic compounds including late-stage labelling of natural products as well as bioactive molecules and can be readily used for the preparation of deuterated compounds on kg-scale.
