Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Six Years for One Step Towards Unnatural Amino Acid–Controlled Gene Therapy
Stories behind the paper “Restoration of dystrophin expression in mice by suppressing a nonsense mutation through the incorporation of unnatural amino acids” that was recently published in Natural Biomedical Engineering.
Adaptive allocation of COVID-19 vaccines
Dynamic prioritization strategies that are adapted to the evolving epidemiological situation allow achieving multiple objectives simultaneously.
Soft, tough, and fast polyacrylate dielectric elastomer for non-magnetic motor
Here we report a new polyacrylate dielectric elastomer with optimized crosslinking network by rationally employing the difunctional macromolecular crosslinking agent, which possesses desirable modulus (~0.073 MPa), high toughness (elongation ~2400%), and rapid response (bandwidth above 100 Hz).
On Paranoia and the Pandemic
The COVID-19 pandemic has made the world seem less predictable. We found that real-world uncertainty increased paranoia and influenced laboratory task behaviour.
Stromal signal promotes Chromatin Remodeling and BET inhibitor Resistance in Cancer cells
BRD4 has a pro-tumorigenic role but non-cell-autonomous mechanisms of BRD4 activation need to be elucidated. Here the authors unravel a mechanism by which CAFs activate BRD4 and induce resistance to BET inhibitors in cancer cells through IL6/IL8 signaling.
