Supramolecular engagers of tumour cells and T cells with an ‘off’ switch

The off-tumour toxicity of a supramolecular bispecific T-cell engager can be halted by disengaging T cells from the tumour cells via the disassembly of the supramolecular aggregate through the infusion of the small-molecule drug amantadine.

Share this post

Choose a social network to share with, or copy the shortened URL to share elsewhere

This is a representation of how your post may appear on social media. The actual post will vary between social networks

The cover illustrates the small-molecule-mediated control of the antitumour activity of a supramolecular bispecific T-cell engager through its disassembly.

See Gong et al.

Image: Ningqiang Gong. Cover design: Alex Wing.

Please sign in or register for FREE

If you are a registered user on Research Communities by Springer Nature, please sign in