In this Nature paper, Ashley Moffett and colleagues describe 3D human trophoblast culture systems (or "mini-placentas") that organize into villous-like structures and secrete various placenta-specific factors. These organoids can differentiate into extravillous trophoblast cells, an important feature of placentation, and transcriptional and methylome profiling show that they resemble first trimester trophoblasts. In the future, the mini-placentas could provide new insights into the human placenta and pregnancy disorders related to placental dysfunction.
Like
Be the first to like this
Follow the Topic
Biotechnology
Life Sciences > Biological Sciences > Biotechnology
-
Nature Biotechnology
A monthly journal covering the science and business of biotechnology, with new concepts in technology/methodology of relevance to the biological, biomedical, agricultural and environmental sciences.
Please sign in or register for FREE
If you are a registered user on Research Communities by Springer Nature, please sign in