Bilateral skeletonized IMAs used as “in situ” grafts for different coronary territories: long-term propensity matching study

Our results suggest that BIMA grafting should no longer be reserved for a select few. With careful technique and experience, it’s not only feasible—it significantly improves survival.

Published in Biomedical Research and Surgery

Bilateral skeletonized IMAs used as “in situ” grafts for different coronary territories: long-term propensity matching study
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Bilateral skeletonized IMAs used as “in situ” grafts for different coronary territories: long-term propensity matching study - Indian Journal of Thoracic and Cardiovascular Surgery

Introduction Bilateral internal mammary arteries (BIMAs) are the most advanced surgical option for coronary artery bypass grafting (CABG). This study compares outcomes between patients receiving skeletonized BIMAs as in situ grafts for different coronary territories and those undergoing CABG with a single internal mammary artery (SIMA). Methods Between 2013 and 2023, 7543 patients underwent CABG for multivessel coronary artery disease at our institution. BIMA grafting was performed in 1133 patients (15.02%), with in situ BIMA grafting in 283 patients (3.75%). The right internal mammary artery (RIMA) was used for the right coronary artery, and the left internal mammary artery (LIMA) for the left anterior descending artery. Propensity score matching yielded 280 patients in each group for comparison. Primary outcomes were 30-day and 10-year all-cause mortality. Secondary outcomes included length of hospital stay, incidence of postoperative major adverse cardiovascular and cerebrovascular events (MACCE), sternal wound infection, and the need for subsequent revascularization. Results There was no 30-day postoperative mortality, perioperative MACCE, or deep sternal wound infection in either group. Mean follow-up was 9.78 ± 0.62 years. The 10-year survival rate was significantly higher in the in situ BIMA group (86.07 ± 3.0%) compared to the SIMA group (78.6 ± 4.1%, p < 0.05). Conclusion Skeletonized BIMA grafting improves long-term survival compared to SIMA grafting, rendering traditionally accepted limitations for BIMA usage irrelevant. These findings support the broader adoption of BIMA grafting in CABG. Graphic abstract

Overall results
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1. What motivated this research?

Despite decades of evidence supporting the use of bilateral internal mammary arteries (BIMAs) in coronary artery bypass grafting (CABG), their adoption remains disappointingly low in routine practice. Concerns about technical complexity, sternal wound complications, and patient comorbidities continue to discourage many surgeons from utilizing this superior revascularization strategy.

As a cardiac surgeon with over three decades of experience, I’ve consistently witnessed the long-term benefits of arterial grafting. However, there remained a critical gap in real-world, long-term data evaluating the safety and efficacy of skeletonized, in-situ BIMA grafting in everyday practice.

2. What’s new or different in your study?

This study is one of the few to report nearly 10-year outcomes of skeletonized in-situ BIMA grafting using propensity-matched controls. We demonstrated a clear long-term survival advantage over conventional SIMA grafting with zero perioperative mortality or sternal wound complications.

3. What were the main challenges?

The main challenge was surgical consistency—ensuring a standardized skeletonization technique and avoiding confounding factors over a 10-year period. Another was assembling a well-matched control group for meaningful comparison, which required rigorous data validation.

This study emerged from a simple but pressing question: Are the traditional concerns about BIMA grafting still valid today? 

4. What surprised you the most?

To our surprise—and satisfaction—the BIMA group demonstrated superior long-term survival, zero perioperative mortality, and no deep sternal wound infections, challenging outdated limitations. These results underscore the importance of surgical technique, careful patient selection, and institutional experience in achieving excellent outcomes.

5. Why does this matter for patients or practice?

Our results suggest that BIMA grafting should no longer be reserved for a select few. With careful technique and experience, it’s not only feasible—it significantly improves survival.

6. Final personal reflection or message to peers

Through this research, we aim to shift the mindset from "BIMA is risky" to "BIMA is standard—when done right." We hope this encourages broader use of this technique, ultimately improving long-term results for patients undergoing CABG.

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Biomedical Research
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