Collection Highlight: Fibrosis, Cancer, and SDG3

In this post, we discuss how an article collection in Journal of Translational Medicine contributes to achieving the Sustainable Development Goal 3: Good Health and Wellbeing goal.

Published in Biomedical Research

Collection Highlight: Fibrosis, Cancer, and SDG3
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Cover of Journal of Translational MedicineJournal of Translational Medicine is an open-access multidisciplinary journal that serves as a bridge to optimize communication between basic and clinical science. As a platform from bench-to-bedside research, it publishes in specialized sections relevant to the Sustainable Development Goal 3 (SDG3): Good Health and Wellbeing, set by the United Nations.

A key target of SDG3 is to reduce premature mortality from non-communicable diseases (target 3.4), specifically in relation to mortality rates attributed to cardiovascular disease, cancer, diabetes or chronic respiratory disease (3.4.1) by 2030. 

Journal of Translational Medicine contributes to the global efforts of researchers and clinicians to meet this target by publishing high-quality articles across several expert-led sections such as Cancer Microenvironment, Combination Strategies, Immune RadioBiology, and Translational Cancer Biology.

Immunofluorescent Light Micrograph
of carcinoma cancer cells of the lung.
Normal lung fibroblast cells are green.
Smaller carcinoma cells (red) are seen
growing upon this fibroblast lung tissue.
Both cell types have blue nuclei.

In 2023, the launch of the Fibrosis section, focusing on the normal and pathogenetic processes of tissue repair, led to the Fibrosis and Cancer Intersection (FACI) article collection. With research implicating fibrosis in the proliferation and migration of cancer cells, the collection was timely and has garnered over 40,000 article accesses.

Guest Editors Dr Mary Salvatore (Vice Chair of Education for Department of Radiology at Columbia University) and Dr Monica Pernia (Columbia University) expressed their objective for the collection in an Editorial:

The improved understanding of how fibrosis develops, causes morbidity, and promotes cancer is the foundation for making advances in diagnosis, treatment, and ultimately prevention.”

This year's theme for World Cancer Day (4th February), "United by unique", highlights how every experience with cancer is unique. Hence, the  FACI article collection is particularly topical in demonstrating this through the discussion of different types of cancers (breast cancer, lung cancer, ovarian cancer, pancreatic cancer, and prostate cancer), the systems affected (thoracic, abdominal, and genitourinary organs), and the treatments involved (immunotherapy, radiotherapy and other therapeutic interventions).


Dr Salvatore (Left) and Dr Pernia (Right)

In line with SDG3 target 3.4, the Guest Editors explain that a collection like Fibrosis and Cancer Intersection which is aimed at “increasing the understanding of the relationship between fibrosis and cancer development would be of great benefit for the medical scientific community since this knowledge could accelerate the development of new therapies to treat cancer while increasing the hostility of the cancer cells’ microenvironment by preventing or interfering with collagen deposition. This evidence could explain the development of tumoral resistance to immune defenses and existing or emergent anti-cancer therapies.” 

We invite you to check out the Fibrosis and Cancer Intersection article collection!


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Related Collections

With collections, you can get published faster and increase your visibility.

Regeneration and Remodeling after Brain Injury: Implications for Stem Cell Therapy

Brain injury/damage, including brain trauma or stroke, has a high morbidity and mortality, and is often accompanied by severe neurological deficits post injury. Despite advances in therapeutics targeting brain repair and remodeling, positive clinical outcome is still a challenge and there continues to be a tremendous unmet clinical need for patients. Currently, transplantation of stem cells derived from several tissue sources has been recognized as very promising biologic-based therapy for regeneration and remodeling after brain injury, for instance, neural stem cells (NSCs), mesenchymal stem cells (MSCs) and induced pluripotent stem cells (iPS cells).

Upon brain injury, oxidative stress and inflammatory response are two early events in the biological cascade following brain injury. These two events are work synergistically and directly trigger the process of autophagy. Appropriate autophagy would contribute to brain recovery by reducing oxidative stress and inflammatory responses, whereas autophagy dysfunction exacerbates brain injury. Various studies have demonstrated that stem cells and their regenerative properties could impact tissue damage following brain injury in the following aspects: cellular replacement, secreting neurotrophic factors, and mitochondrial transfer. This collection aims to discuss the recent progress on stem cell therapy for brain injury, specifically studies elucidating the mechanisms in terms of oxidative stress, mitochondrion dysfunction and autophagy.

The collection welcomes all original and review articles on topics such as:

-Stem cell therapy for brain repair after brain injury/damage, including brain trauma or stroke;

-Underlying mechanisms upon stem cell replacement for brain injury, including cellular/tissue regeneration/remodeling, oxidative stress, inflammatory response and autophagy;

-Immune-response problems following stem cell therapy for brain injury;

-Mitochondrial role after stem cell therapy for brain injury;

-Detection of stem cell therapy for brain injury using imaging techniques, i.e. brain magnetic resonance;

Application of new tools, techniques, or models for studying stem cell viability or survival after implantation, such as organoids.

All submissions in this collection undergo the journal’s standard peer review process. Similarly, all manuscripts authored by a Guest Editor(s) are handled by the Editor-in-Chief. As an open access publication, this journal levies an article processing fee (details here). We recognize that many key stakeholders may not have access to such resources and are committed to supporting participation in this issue wherever resources are a barrier. For more information about what support may be available, please visit OA funding and support, or email OAfundingpolicy@springernature.com or the Editor-in-Chief.

Publishing Model: Open Access

Deadline: Ongoing

Microbiome in the first 1000 days of life

This collection aims to highlight recent advances in microbiome research during early life, focusing on its dynamics, impact on immune development, metabolism, and neurodevelopment, as well as potential interventions to promote a healthy microbiome. We welcome original research and review articles covering topics such as: 1. The role of the maternal microbiome in shaping infant microbiome development. 2. The impact of pregnancy complications on early-life microbiome composition. 3. Role of the human milk microbiome on infant’s health. 4. The influence of antibiotics and other early-life exposures on microbiome maturation. 5. The gut-brain axis: microbiome interactions and neurodevelopmental outcomes. 6. Interventions to promote a healthy microbiome, including probiotics, prebiotics, and dietary modifications

All submissions in this collection undergo the journal’s standard peer review process. Similarly, all manuscripts authored by a Guest Editor(s) will be handled by the Editor-in-Chief. As an open access publication, this journal levies an article processing fee (details here). We recognize that many key stakeholders may not have access to such resources and are committed to supporting participation in this issue wherever resources are a barrier. For more information about what support may be available, please visit OA funding and support, or email OAfundingpolicy@springernature.com or the Editor-in-Chief.

This Collection supports and amplifies research related to SDG 3, Good Health and Well-Being.

Publishing Model: Open Access

Deadline: Dec 17, 2025