This collection is dedicated to advancing our understanding of chronic disease management through the lens of health systems innovation. We invite original research articles and rigorous reviews (systematic, narrative, or scoping) that examine how integrated care models and advanced health service frameworks can transform the management of long-term conditions. Our aim is to highlight research that connects clinical practice with the operational, organizational, and financial structures of health systems.

Submissions should focus on studies that explore and evaluate innovative approaches to care delivery within health systems, highlighting topics such as:

• Integrated Care Models: Investigations into coordinated care strategies that align medical and nursing practices with broader service delivery systems, ensuring seamless transitions between primary, secondary, and community care.

• Organizational Innovations: Evaluations of new management models and care strategies that optimize resource allocation, enhance patient safety, and streamline service delivery within complex health systems.

• Nurse-led and Multidisciplinary Care: Analyses of care strategies led by nursing professionals and multidisciplinary teams, emphasizing their roles in facilitating patient-centered care within structured health service environments.

• Health Economics and Service Sustainability: Economic evaluations and cost-effectiveness analyses of chronic care interventions that inform policy and practice changes within health systems.

• Digital Health and Care Coordination: Studies on the implementation and impact of digital technologies and telemedicine in improving chronic care management, with a focus on enhancing system-wide efficiency and patient outcomes.

• Health System Reforms: Research on policy-driven and organizational reforms aimed at integrating chronic disease management into the broader health services framework, ensuring that care models are both sustainable and scalable.

This collection of articles aims to explore and promote the synergy between clinical excellence and health system innovation, with the goal of highlighting how robust service delivery models can not only optimize clinical outcomes but also enhance patient satisfaction and improve overall quality of life. We are seeking studies that deeply address the operational, financial, and organizational aspects of chronic care within health systems, emphasizing the critical role of a well-structured healthcare system in supporting the treatment and management of chronic diseases.

In particular, we welcome manuscripts that explore innovative approaches to the design and implementation of healthcare services, with a focus on integrated care models, financial sustainability, and organizational efficiency. Our intention is to create a collection that not only contributes to high-quality academic research but also influences healthcare policies globally, providing practical and applicable solutions to address the challenges of international healthcare systems.

Keywords: Chronic disease care, Community Care, nursing care, patient engagement, health economic evaluation

Health informatics is transforming modern healthcare through the integration of emerging technologies such as advanced data analytics and artificial intelligence. These advancements aim to optimize patient outcomes, streamline clinical workflows, and support evidence-based decision-making. This collection seeks to highlight pioneering research on critical areas such as electronic health records, predictive modeling, telemedicine, and cybersecurity in healthcare systems. We invite submissions of original research articles, comprehensive reviews, and case studies that demonstrate innovative applications and explore future directions in the field of health informatics.

Keywords: Medical Data Analytics, Artificial intelligence, digital health technologies, Clinical Decision Support Systems, Biomedical Informatics